Manganese-enhanced MRI of axon regeneration by peptide nanofiber scaffold induction

Abstract

In this study, manganese-enhanced magnetic resonance imaging (MEMRI) was performed to demonstrate neuroregeneration upon induction by a selfdesigned, self-assembly peptide nanofiber scaffold (SAPNS)in the wounded site being left untreated for 3 months. The optic tracts of 8 adult Syrian hamsters were severed at the brachium of the left superior colliculi, and MEMRI was performed 1 week before and 1.5 months after SAPNS treatment. Results showed that the signal intensity at the SAPNS treated superior colliculus increased significantly by about 10%. This indicated a potential restoration of neural connection across the wounds