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research
Effect of 2-(3-carboxy-1-oxopropyl) amino-2-deoxy-D-glucose on human esophageal cancer cell line
Authors
R Ji
WM Liu
+6 more
H Lu
L Qiao
AQ Wang
J Wu
QJ Xue
Y Zhou
Publication date
1 January 2004
Publisher
'Baishideng Publishing Group Inc.'
Doi
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on
PubMed
Abstract
Aim: To determine whether 2-(3-carboxy-1-oxopropy1) amino-2-deoxy-D-glucose (COPADG), a derivative of D-amino-glucose, inhibited the growth of human esophageal cancer cell line Eca-109. Methods: Effects of COPADG on Eca-109 cells cultured in RPMI 1640 medium were examined by a tetrazolium-based colorimetric assay (MTT assay). Results: COPADG inhibited the growth of Eca-109 cells in a dose- and time-dependent manner; the maximum inhibition rate was 83.75%. Conclusion: COPADG can directly inhibit the proliferation of Eca-109 cells, which may serve as the experimental evidence for development of new drugs for esophageal cancer therapy. Copyright © 2004 by The WJG.published_or_final_versio
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Last time updated on 01/06/2016