Cao, CF

Jin, LJ

Kang, J

Sha, YQ

Journal of Dental Research

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Title Effect of a Chinese herbal medicine on chronic periodontitispatientsAuthor(s) Kang, J; Sha, YQ; Jin, LJ; Cao, CFCitationThe 6th Annual Scientific Meeting of the InternationalAssociation for Dental Research (Chinese Division), Shanghai,China, 24-25 October 2005. In Journal of Dental Research, 2005,v. 84 Sp Iss  BIssued Date 2005URL http://hdl.handle.net/10722/53812Rights Creative Commons: Attribution 3.0 Hong Kong LicenseEffect of a Chinese herbal medicine on chronic periodontitis patients J. KANG1, Y.-Q. SHA2, L. JIN3, and C.-F. CAO1, 1Peking University, School of Stomatology, Beijing, China, 2Peking University, Beijing, China, 3University of Hong Kong, Hong Kong  Objectives: A randomized, single-blinded case-controlled trial was designed to evaluate the effect of a Chinese herbal medicine (HM) as adjunct of scaling and root planning (SRP) in advanced chronic periodontitis (CP) patients. Methods: 30 advanced CP patients (7M,23F) aged 20 to 45 years old were enrolled . Subjects were generally healthy, non-smokers,and had no periodontal treatment before. Each patient had at least 3 teeth in each quadrant with PD>5mm,CAL>3mm. From each patient 5-6 most severely diseased tooth sites were monitored throughout the study. Periodontal parameters including probing depth (PD) and clinical attachment loss (AL) using Florida Probe, bleeding index (BI), and GCF volume were recorded at baseline and 3,6,9,12 months after treatment. Alveolar bone was analyzed by digital subtraction radiography (DSR) at baseline and 6,12 months. All subjects received thorough full mouth SRP. Then,they were randomly assigned to test group (15 patients, 82 sites) and control group (15 patients, 78 sites). Group-T orally took a marketed HM named BUSHEN GUCHIWAN (4.0g, bid) for three months. Group-C took no medicine. During each recall visit both groups received OHI and prophylaxis and clinical parameters recorded. Results: 24 patients attended 6-month recall. 13 patients completed 12-month survey. Both groups showed significant improvement in all parameters after treatment at all visits. However, group-T showed additional improvements. At 6-month, PD reduced 2.48mm in group-T compared to 2.19mm in group-C; AL improved 1.61mm and 1.08mm, respectively; GCF reduced 0.37µl in group-T vs 0.26µl in group-C; BI decreased 1.45 and 1.32, respectively. The inter-group differences in clinical data peaked at 6-month (P<0.01). DSR analysis showed the increased bone density in group-T was 4.99±2.76 vs 3.27±2.28 in group-C (P<0.05) at 6-month and continued growing until 12-month (6.54±3.01 vs 4.30±3.38, P<0.05). Conclusions: The “Bushen Guchiwan” may contribute to the adjunct effect of SRP for advanced chronic periodontitis patients.    Periodontal Research - Therapy  The Preliminary Program for 6th Annual Scientific Meeting of the IADR Chinese Division (October 24-25, 2005)  

Effect of a Chinese herbal medicine on chronic periodontitis patients

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Effect of a Chinese herbal medicine on chronic periodontitis patients

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