Chai, L

Leung, WK

Song, YQ

Zee, KY

Journal of Dental Research

HKU Scholars Hub

Title Association between FCGR3A polymorphisms and periodontitisin Hong Kong ChineseAuthor(s) Chai, L; Leung, WK; Zee, KY; Song, YQCitationThe 21st Annual Scientific Meeting of the InternationalAssociation for Dental Research (Southeast Asia Division) &18th Annual Scientific Meeting of the Southeast AsiaAssociation for Dental Education, Bali, Indonesia, 6-8 September2007. In Journal of Dental Research, 2007, v. 86 Sp Iss BIssued Date 2007URL http://hdl.handle.net/10722/57227Rights Creative Commons: Attribution 3.0 Hong Kong LicenseAssociation Between FCGR3A Polymorphisms and Periodontitis in Hong Kong Chinese L. CHAI, The University of Hong Kong, Hong Kong, W.K. LEUNG, The University of Hong Kong, Hong Kong SAR, Hong Kong, K.Y. ZEE, University of Sydney, Austria, and Y.Q. SONG, University of Hong Kong, Hong Kong SAR, China  Genetic polymorphisms are believed to be associated with periodontitis. Objective: To compare single nucleotide polymorphisms (SNPs) in coding and regulatory regions of the Fc gamma receptor IIIa (FCGR3A) gene of individuals with or without periodontitis in order to determine whether any genetic polymorphisms are associated with periodontitis in Hong Kong. Methods: 204 patients with periodontitis and 217 periodontitis-free subjects were recruited from the patient pool of the Faculty of Dentistry, The University of Hong Kong. DNA was extracted from whole blood taken from the subjects. The samples were genotyped by the Sequenom MassARRAY system using specific primers and directly sequenced. Chi-square test was used to analyze the association between genotype distribution and periodontitis. Results: Most of the SNPs studied did not show any significant associations with periodontitis. Genotype TT of the SNP rs2290834(C/T) was more frequently observed in the patient group than genotypes CC or CT (odds ratio, 4.94; 95% confidence interval, 2.86~8.54; p<0.001). Conclusion: SNP rs2290834 in the coding region of FCGR3A may be associated with periodontitis in the Hong Kong Chinese population. (Supported by URC grant 10206094.)   Periodontal Research - Pathogenesis  The Preliminary Program for 21st International Association for Dental Research - South East Asia Division : Annual Research Meeting  

Association between FCGR3A polymorphisms and periodontitis in Hong Kong Chinese

http://hub.hku.hk/bitstream/10722/57227/1/143998.pdf

Association between FCGR3A polymorphisms and periodontitis in Hong Kong Chinese

Abstract

Similar works

Full text

Available Versions

HKU Scholars Hub