Anti-beta2 glycoprotein I (beta2GPI) antibodies facilitates phagocytosis of apoptotic neutrophils in patients with systemic lupus erythematosus (SLE)

Abstract

BACKGROUND : Increased apoptosis provides a continuous source autoantigens and has been suggested to have a pathogenic role in SLE. We have previously shown patients with SLE have impaired clearance of apoptotic bodies. In this study, we evaluated whether anti-beta2GPI antibodies, a subset of antiphospholipid antibodies, may have an effect on the phagocytosis of apoptotic bodies by macrophages in these patients …published_or_final_versio