Chow, WS

Shiu, SWM

Tan, KCB

Wong, Y

Hong Kong Medical Journal

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TitleCorrelation between plasma phospholipid transfer proteinactivity and low density lipoprotein subfractions pattern insubjects with type 2 diabetes mellitusAuthor(s) Chow, WS; Tan, KCB; Shiu, SWM; Wong, YCitationThe 8th Medical Research Conference, Hong Kong, China, 25-26January 2003. In Hong Kong Medical Journal, 2003, v. 9 n. 1Supp 1, p. 35Issued Date 2003URL http://hdl.handle.net/10722/46689Rights Creative Commons: Attribution 3.0 Hong Kong LicenseHKMJ Vol 9 No 1 February 2003 Supplement      35Correlation between plasma phospholipid transfer protein activity and lowdensity lipoprotein subfractions pattern in subjects with type 2 diabetes mellitusWS Chow, KCB Tan, SWM Shiu, Y WongDepartment of Medicine, University of Hong Kong, Queen Mary Hospital, Hong KongIntroduction: Phospholipid transfer protein (PLTP) plays an important role in the remodelling of high densitylipoprotein (HDL) by facilitating the transfer of phospholipids between lipoproteins. It may also enhance cholesterylester transfer mediated by cholesteryl ester transfer protein (CETP). Since the formation of small dense low densitylipoprotein (LDL) also involves lipid exchange between LDL particles and triglyceride-rich lipoproteins, we haveinvestigated the relationship between plasma PLTP activity and LDL subfractions pattern in patients with type 2diabetes mellitus (DM).Methods: 240 subjects with type 2 DM and 136 controls were recruited. All subjects were non-smokers and non-drinkers. Plasma PLTP activity was evaluated by measuring the transfer of radiolabelled phosphatidyl-choline fromliposomes containing radiolabelled phosphatidylcholine to plasma HDL. LDL subfractions were determined bydensity gradient ultracentrifugation.Results: The diabetic subjects had higher plasma triglyceride (p<0.001) and lower HDL (p<0.001) than the non-diabetic controls. They also had significantly higher concentration of small dense LDL-III (118.7 mg/dl ± 52.8 vs88.0 ± 45.3, p<0.001). Plasma PLTP activity was increased in the diabetic patients (2.09 umol/ml/h ± 0.54 vs 1.60± 0.41, p<0.001) and the difference remained significant after adjusting for age, sex, body mass index. There was anassociation between plasma PLTP activity and HbA1c (r = 0.17, p<0.01) but no correlations were found betweenplasma PLTP activity, triglyceride or HDL. However, plasma PLTP activity correlated with small dense LDL-IIIconcentration (r = 0.29, p<0.001).Conclusions: The diabetic subjects have higher concentration of small dense LDL-III and plasma PLTP activity.The positive correlation between these two parameters in subjects with type 2 DM suggested that PLTP might beinvolved in the formation of small dense LDL particles by facilitating lipid exchange.High blood pressure is related to obesity in Hong KongBMY Cheung, YB Man, JLF Lo, DFY Chau, CY Law, KSL Lam, TH Lam,1 NMS Wat, SCF Tam,2 CH Cheng, CR Kumana,CP Lau. University Department of Medicine, Department of Community Medicine,1 The University of Hong Kong; ClinicalBiochemistry Unit,2 Queen Mary Hospital, Hong KongIntroduction: Obesity predisposes to the development of hypertension. We have previously found that blood pres-sure correlated with indices of obesity in Hong Kong Chinese. We sought to confirm this association in subjectsrandomly chosen from the general population.Method: 813 subjects (393 men, 420 women; age 51±12 yrs) recruited for the Hong Kong Cardiovascular RiskFactor Prevalence Survey-2 (CRISPS2) were studied. 214 of them were hypertensive (systolic blood pressure ≥ 140mmHgor diastolic blood pressure ≥ 90 mmHg or taking antihypertensive medication) and the other 599 were normotensive.The medical history was obtained and the subjects were examined with special attention to blood pressure andindices of obesity. Body fat was assessed using bioelectrical impedence.Results: Diastolic blood pressure (DBP) was related to age (r=0.16, p<0.001) and indices of obesity including bodymass index (r=0.35, p<0.001), body fat (r=0.12, p=0.004), waist circumference (WC) (r=0.40, p<0.001) and waist-to-hip ratio (r=0.35, p<0.001). Systolic blood pressure (SBP) was also related to age (r=0.50, p<0.001), WC(r=0.37, p<0.001) and the other indices of obesity. Multiple regression analysis suggested that WC (ß=0.40, p<0.001)was the only independent predictor of DBP, whereas age (ß=0.45, p<0.001) and WC (ß=0.23, p<0.001) wereindependent predictors of SBP (R2=0.30, p<0.001). DBP correlated with WC in both men (r=0.32, p<0.001) andwomen (r=0.37, p<0.001). Similarly, SBP correlated with WC in both men (r=0.20, p<0.001) and women (r=0.40,p<0.001).Conclusions: Our results confirm that blood pressure is related to obesity. WC is a simple measurement and a goodpredictor of blood pressure, especially in women. As the relationship between blood pressure and obesity is continuous,tackling obesity in the community as well as in hypertensive individuals may reduce the incidence and prevalenceof hypertension and other cardiovascular risk factors.EM-09EM-10

Correlation between plasma phospholipid transfer protein activity and low density lipoprotein subfractions pattern in subjects with type 2 diabetes mellitus

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Correlation between plasma phospholipid transfer protein activity and low density lipoprotein subfractions pattern in subjects with type 2 diabetes mellitus

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