Ambekar, CS

Cheung, BMY

Kumana, CR

Liang, RHS

Hong Kong Medical Journal

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Title Traditional Chinese medicine: effect on bone marrow andperipheral blood cell counts and enzyme inductionAuthor(s) Ambekar, CS; Kumana, CR; Liang, RHS; Cheung, BMYCitationThe 8th Medical Research Conference Abstracts, Hong KongMedical Journal, Hong Kong, China, 25-26 January 2003, v. 9 n. 1Supp 1, p. 63Issued Date 2003URL http://hdl.handle.net/10722/46922Rights Creative Commons: Attribution 3.0 Hong Kong LicenseHKMJ Vol 9 No 1 February 2003 Supplement      63Non-myeloablative allogeneic peripheral stem cell transplantation in multiplemyeloma: 2 years experience in a single centerSY Ma, AKW Lie, WY Au, CS Chim, Eric Tse, YL Kwong and R LiangDepartment of Medicine, Queen Mary Hospital, University of Hong Kong.Multiple myeloma (MM) is considered non-curable by chemotherapy alone and the role of standard allogeneicstem cell transplantation (allo-SCT) remains controversial because of relatively high treatment related mortality(TRM). Non-myeloablative allo-SCT is associated with satisfactory engraftment but less toxicity which is essentialin the heavily pretreated elderly patient with multiple myeloma. We report our 2 years experience on 10 MMpatients receiving non-myeloablative allogeneic PBSC transplantation using fludarabin (30mg/m2)/TBI (150 Gy)as conditioning. 8 patients had full HLA-matched siblings donor, 1 had a one major HLA-antigen mismatchedsiblings and the last one had a full HLA-matched daughter donor. All patients had active disease before SCT withsatisfactory engraftment before D21. No TRM was observed during the whole follow up period. Acute GVHDdeveloped in 3 patients (2 at grade III and 1 at grade IV) and 7 patients had chronic GVHD (3 acute GVHD casesincluded). At a median follow up of 1 year, 2 patients had complete remission (CR), 3 patients had partial response(PR), 3 patients had no response (NR) and 2 patients were too early for assessment. No relapse case was observed.Only one NR patients had donor lymphocyte infusion (DLI) and 2 NR patients had thalidomide. In conclusion,non-myeloablative allo-SCT in multiple myeloma is effective with less toxicity and TRM. However, a longer fol-low up period and more cases are required before a definite conclusion can be reached.HO-13Traditional Chinese medicine: effect on bone marrow and peripheral blood cellcounts and enzyme inductionAmbekar CS, Kumana CR, Liang R and Cheung BMY.Department of Medicine, The University of Hong Kong.Herbal Medicines are important source of pharmacologically active compounds. While studying metabolism ofchloramphenicol succinate (CAPS) by bone marrow, we observed that marrow and blood sample obtained from asingle marrow donor (A) contained large amounts of an enzyme that metabolized CAPS to 3 metabolites within 15 minof incubation. While other 2 donors (B and C) marrow also metabolized CAPS to 3 metabolites after 3 hoursincubation and in remaining 72 marrow samples CAPS was metabolized to one metabolite after 3-24 hrs incubation.Both marrow and blood cell counts (WBC, RBC, Platelets) were also high in this donor (A) as compared to all othermarrow donors’ marrow and blood cell counts. This donor was pre-treated with TCM (Siu Fung San) for his allergicreaction 10 days prior to marrow donation. Some in vitro cell culture studies were also conducted to see its effectson cell proliferation and CAPS metabolising enzyme. We could not see any enzyme induction effect by usingin vitro method. It is possible that when given orally herbs may undergo metabolism and active components may bedistributed to each tissue. These active components may induce cell proliferation, enzymes and protein synthesis.We conclude that “Siu Fung San” a Traditional Chinese Medicine taken prior to marrow and blood donation by ourone marrow donor may be responsible for his high bone marrow and peripheral blood cell counts and large amountof succinate dehydrogenase.HO-14

Traditional Chinese medicine: effect on bone marrow and peripheral blood cell counts and enzyme induction

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Traditional Chinese medicine: effect on bone marrow and peripheral blood cell counts and enzyme induction

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