Cheung, BMY

Ho, SPC

Lau, CP

HKU Scholars Hub

TitleRandomised placebo-controlled study of the effect of fosinoprilon left ventricular mass in untreated hypertensive patients:  finalresultsAuthor(s) Cheung, BMY; Ho, SPC; Lau, CPCitation The 5th Medical Research Conference, Hong Kong, China,January 2000, v. 22 n. Supp 2, p. 34Issued Date 2000URL http://hdl.handle.net/10722/46871Rights Creative Commons: Attribution 3.0 Hong Kong LicenseS-C-15Expression of Macrophage Migration Inhibitory Factor in Acute Myocardial InfarctionCM Yu, Lai KWH. *HY Lan, CP Lau. Division of Cardiology and *Division of Molecular Pathology,Department of Medicine, Queen Mary Hospital, Hong KongBackground: Myocardial remodeling after acute myocardial infarction (AMI) contributes to the developmentof cardiac failure and late mortality. Its pathogenic mechanism is not entirely understood. Macrophage MigrationInhibitory Factor (MIF) is a chemokine that involves in the regulation of inflammatory and immune responses.Therefore, we hypothesize that MIF is activated in the course of AMI which might have pathological importancein the myocardial remodeling, which has not been shown before.Methods: An animal model of AMI was established by ligating the left anterior descending coronary arteriesof the 10-week old male Sprague-Dawley rats. Thirty post-AMI were killed at 3 hr, 6 hr, 1 day, 3 days and7days. Six sham-operated rats were used as controls. The expression of MIF was revealed and estimated byimmunohistochemistry and western blot. The macrophage infiltration was also studied by immunohistochemicalmethod using anti-EDl antibody.Results: Immunostaining of MIF in AMI heart showed that it was expressed mainly at the peri-infarct zone inthe left ventricle, mainly from the myocytes. A lower of expression was found at the septum and right ventricle.The amount of staining was more abundant from 1 day to 7 days after AMI. Macrophage infiltration at theinfarct area was found after 3 days and increased after 7 days of AMI, which confirmed the chemotactic effectof MIF on these cells.Conclusion: We have demonstrated for the first time that after AMI, MIF expression is increased at the peri-infarcted zone. Macrophages infi l trat ion are also involved in AMI, but after the onset of MIF expression.Therefore MIF may act as a modulator that regulates the macrophage functions, and thus influencing theprocess of myocardial remodeling.S-CH-1RANDOMISED PLACEBO-CONTROLLED STUDY OF THE EFFECT OF FOSINOPRIL ON LEFTVENTRICULAR MASS IN UNTREATED HYPERTENSIVE PATIENTS: FINAL RESULTSCheung BMY. Ho SPC, Lau CP. Department of Medicine, University of Hong Kong, Hong KongObjective: Left ventricular hypertrophy is a powerful predictor of cardiovascular morbidity and mortality. Wetested the hypothesis that fosinopril, an angiotensin-converting enzyme inhibitor, reduces left ventricular massin hypertensive patients.Design and Methods: 54 patients (M:F, 34:20; age 48± 14 yrs) with untreated mild essential hypertensionwere randomised to treatment with oral fosinopril (10mg-20mg daily) or placebo for 12 weeks. No additionaldrugs were allowed. The primary outcome measure was the change in left ventricular mass index determinedby echocardiography.Results: Diastolic blood pressure changed from 97.2± 1.8 mmHg at baseline to 98.1 ±2.3 mmHg at the finalvisit in control patients and changed from 99.2±2.0 mmHg to 96.0±2.5 mmHg in patients treated with fosinopril(p = 0.05). Systolic blood pressure changed from 147.9±2.6 mmHg at baseline to 151.1±3.4 mmHg at thefinal visit in control patients and changed from 159.2±4.2 mmHg to 149.1±4.5 mmHg in patients treated withfosinopril (p = 0.01). The left ventricular mass index changed from 110.3± 6.1 g/m2 to 114.3±8.7 g/m2 incontrol patients and changed from 133.4± 9.2 g/m2 to 127.1± 11.0 g/m2 in patients treated with fosinopril(p = 0.03). There was no significant change in the left ventricular systolic or diastolic function, nor were thereany significant changes in plasma electrolytes and renal function.Conclusion: Treatment with fosinopril as monotherapy for 12 weeks reduces left ventricular mass inhypertensive patients.- 34 -

Randomised placebo-controlled study of the effect of fosinopril on left ventricular mass in untreated hypertensive patients:  final results

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Randomised placebo-controlled study of the effect of fosinopril on left ventricular mass in untreated hypertensive patients: final results

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