Cheung, AHK

Cheung, BMY

Lau, CP

Leung, RYH

HKU Scholars Hub

Title Family history of hypertension is related to angiotensin-converting enzyme genotypeAuthor(s) Cheung, BMY; Cheung, AHK; Leung, RYH; Lau, CPCitation The 5th Medical Research Conference, Hong Kong, China,January 2000, v. 22 n. Supp 2, p. 3Issued Date 2000URL http://hdl.handle.net/10722/46866Rights Creative Commons: Attribution 3.0 Hong Kong LicenseG-CH-2FAMILY HISTORY OF HYPERTENSION IS RELATED TO ANGIOTENSIN-CONVERTINGENZYME GENOTYPECheung BMY. Cheung AHK, Leung RYH, Lau CP. Department of Medicine, University of Hong Kong, HongKongObjective: Insertion/deletion (I/D) polymorphism of the angiotensin converting enzyme (ACE) gene isassociated with coronary heart disease, but the association with hypertension is weak. We examined therelationship between ACE genotype and family history of hypertension in hypertensive patients.Methods: 48 hypertensive patients (25 men, 23 women; 51± 12 yrs) were questioned in detail about theirfamily history of hypertension. Hypertension was assumed if the relative had been diagnosed and treated forhypertension. Unknowns were invited to have their blood pressure checked. DNA was extracted from 5 mlvenous blood obtained with consent. Insertion (I) and deletion (D) alleles were identified after amplificationby PCR and electrophoresis.Results: The number of normotensive (NT) and hypertensive (HT) siblings (mean ± SD), and the proportion ofhypertensive siblings in each family are as follows:DDIDIIN9182148no. of NT sibs0.4+0.82.4 + 2.72.7 + 2.3no. of HT sibs1.6±1.60.9+1.40.6+0.8% HT sibs90 ±2360 ±3548 ±32p = 0.005Conclusions: DD patients are more likely to have hypertensive siblings and less likely to have normotensivesiblings. The high prevalence of hypertension in the close relatives of DD patients needs to be confirmed byfurther studies.G-CH-3IS SYSTOLIC BLOOD PRESSURE RELATED TO POTASSIUM EXCRETION?Cheung BMY. Cheung AHK, Lau CP, Kumana CR. Department of Medicine, The University of Hong Kong,Hong KongIntroduction: We had previously found in untreated hypertensive patients that 24 hour urinary sodium excretioncorrelated with diastolic pressure (r = 0.52, p = 0.0003, n = 50) and ambulatory diastolic pressure (r = 0.53,p=0.01, n = 22), but not systolic pressure (r = -0.04). Systolic pressure increased with age (0.6+0.2 mmHg/year, p = 0.001) and surprisingly correlated with potassium excretion. We therefore sought to confirm thisprospectively.Methods: 46 consecutive newly-diagnosed untreated hypertensive patients (30 men, 16 women; age 43+11 yrs)were studied. Blood pressure was measured on 3 occasions. Urine was collected for 24 hours for themeasurement of electrolytes.Results: 24 hour urinary potassium excretion correlated with systolic blood pressure (r = -0.53, p < 0.001)(fig.). The correlation remains highly significant even after adjusting for age, gender, body mass index, ethanolintake and season (r = -0.50, p < 0.05). In a multiple regression analysis with systolic pressure as the dependentvariable, the regression coefficient was -7.6+1.7 mmHg/10 mmolK. Although systolic pressure increases withage, this was found only in subjects with below median potassium excretion (<45 mmol/day) (r = 0.56, p<0.01).In patients whose potassium excretion were above median, there was no relationship between systolic pressureand age.Conclusions: In our hypertensive patients, whereas diastolic blood pressure is strongly related to urinarysodium excretion, systolic blood pressure is strongly related to potassium excretion, accounting for 28 % of thevariance. Our findings raise the possibility that a diet rich in potassium, such as through eating more fruits andvegetables, may prevent the seemingly inevitable rise in systolic pressure with age.

Family history of hypertension is related to angiotensin-converting enzyme genotype

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Family history of hypertension is related to angiotensin-converting enzyme genotype

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