特集号 油症とPCB及びダイオキシン関連化合物 研究報告第20集 責任編集者 古江増隆The Twentieth Reports of the Study on Yusho―PCBs and Dioxin-Related Compounds―Guest Editor Masutaka FurueThirty-six years have passed since the outbreak of Kanemi rice oil poisoning, namely, Yusho in the western Japan. However, even now the patients with Yusho have been still suffering from several objective and subjective symptoms. In order to improve or, if possible, to cure the such symptoms, the most important therapeutic treatment is considered to actively excrete the causative agents, that is, polychlorinated dibenzofurans (PCDFs) and polychlorinated dibenzo-p-dioxins (PCDDs) from the bodies of the patients and to reduce their body burdens. In rats, dietary fiber and chlorophyll have been shown to promote the fecal excretion of dioxins and to reduce their levels in rat liver. In this study, we examined whether such kinds of effect were also observed by FBRA, which was the health food and relatively rich with dietary fiber and chlorophyll, in nine married Japanese couples. As a result, concentrations of PCDFs and PCDDs on the lipid weight basis in the blood of the FBRA-intake group in which they took 7.0 to 10.5g of FBRA after each meal and three times a day for one year were more lowered than those in the blood of the nonintake group ; Blood levels of PCDFs and PCDDs in the FBRA-intake group were decreased by 41.0 and 37.2 %, respectively, and those decreases were 33.7 and 29.4 % in the non-intake group. Their total bod y burdens just before and one year after the study were calculated on the assumptions that the body fat was also contaminated with these dioxins at their blood levels on the lipid weight basis and the content of body fat was 20 % of the body weight. Then, we computed the average amounts in excretion of PCDFs and PCDDs from the body in both the FBRA-intake and non-intake groups. Consequently, the amounts of excretion of PCDFs and PCDDs in the FBRA-intake group were 1.81 and 1.74 times, respectively, greater than those in the non-intake group. Therefore, FBRA seemed to promote the fecal excretion of causative agents of Yusho, from the human body. We also expect FBRA to reduce their body burdens of patie nts with Yusho and to improve some objective and subjective symptoms of Yusho patients.カネミ油症中毒事件が発生してから36年が経過したが,今でも油症患者は種々様々な自覚および臨床症状で苦しんでいる.このような症状を改善し治療するには,その主要な原因物質であるポリ塩化ダイベンゾフラン(PCDFs)とポリ塩化ダイベンゾーp一ダイオキシン(PCDDs)を積極的に体外へ排泄し,汚染レベルを低下させることが第一である.この研究では動物実験によりダイオキシン類の体外排泄促進作用が認められている食物繊維と葉緑素を比較的多量に含む栄養補助食品FBRA(発酵玄米栄養補助食品ハイ・ゲンキ,㈱玄米酵素,本社:北海道札幌市)によるカネミ油症原因物質の体外排泄促進を9組の夫婦の協力により調べた.その結果,毎食後7～10.5gのFBRAを1日3回1年間摂取することにより,血液脂質重量当りのPCDFsとPCDDsの濃度が非摂取群よりもそれぞれ6.2%と7.7%低下した.この血液脂質濃度で体脂肪も汚染されており,体脂肪率を体重の20%と仮定し,1人当り1年間の体外排泄量を両化学物質について計算した.そうすると,FBRAを摂取することによりPCDFsとPCDDsの排泄量がそれぞれ1.81倍と1.74倍高まることが示された.以上のような結果より,FBRAは油症原因物質のPCDFsとPCDDsの体外への排泄を促進するので,油症患者の治療にも有効と考えられた
