The study of the interaction between nanoparticles and model of lung surfactant is of great relevance to understand possible adverse effects of inhalable nanoparticles on the respiratory function [1,2]. We report therefore a study on the interfacial properties, structure and dilational rheology of monolayers of the major lipidic component of the lung surfactant, 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), in the presence of silica nanoparticles. Investigations are performed by a Langmuir trough equipped with Brewster Angle Microscopy