We describe a case of chronic hepatitis E virus (HEV) infection in a 13-year-old female liver transplant recipient with recurrent increased aminotransferase levels and acute cellular rejection. This finding demonstrates that chronic HEV infection can occur and should be further investigated in immunocompromised patients in Latin America.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Universidade Federal de São Paulo, Dept Med, Div Infect Dis, São Paulo, BrazilAC Camargo Canc Ctr, São Paulo, BrazilFleury SA Grp, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Med, Div Infect Dis, São Paulo, BrazilFAPESP: 2012/22925-3FAPESP: 2013/03701-0Web of Scienc