II Jornadas Agronómicas Açorianas, Outubro, 1991, Ponta Delgada, Açores.No Arquipélago dos Açores, desde 1970 e com maior incidência na ilha de S. Miguel, devido ao aumento da área de pastagem, com vista ao desenvolvimento da bovinocultura, uma das espécies de Noctuídeos, Mythimna unipuncta (Haworth) (Lepidoptera, Noctuidae), assinalada na região desde 1810
por GODMAN, tornou-se num grave problema económico, estimando-se os seus prejuízos em cerça de 8% da produção anual das pastagens (TAVARES, 1989)

Chaves, Amalia Saturnino

Coutinho, Luiz Lehmann

Decker, Jared E.

Lanna, Dante Pazzanese Duarte

Mourão, Gerson Barreto

Mudadu, Mauricio de Alvarenga

Oliveira, Priscila Silva Neubern

Regitano, Luciana Correia de Almeida

Rosa, Kamila de Oliveira [UNESP]

Schnabel, Robert D.

Souza, Marcela Maria de

Taylor, Jeremy F.

Tizioto, Polyana Cristine

Tullio, Rymer Ramiz

Zerlotini-Neto, Adhemar

PubMed

Abstract\ud
              \ud
                Background\ud
                Efficiency of feed utilization is important for animal production because it can reduce greenhouse gas emissions and improve industry profitability. However, the genetic basis of feed utilization in livestock remains poorly understood. Recent developments in molecular genetics, such as platforms for genome-wide genotyping and sequencing, provide an opportunity to identify genes and pathways that influence production traits. It is known that transcriptional networks influence feed efficiency-related traits such as growth and energy balance. This study sought to identify differentially expressed genes in animals genetically divergent for Residual Feed Intake (RFI), using RNA sequencing methodology (RNA-seq) to obtain information from genome-wide expression profiles in the liver tissues of Nelore cattle.\ud
              \ud
              \ud
                Results\ud
                Differential gene expression analysis between high Residual Feed Intake (HRFI, inefficient) and low Residual Feed Intake (LRFI, efficient) groups was performed to provide insights into the molecular mechanisms that underlie feed efficiency-related traits in beef cattle. A total of 112 annotated genes were identified as being differentially expressed between animals with divergent RFI phenotypes. These genes are involved in ion transport and metal ion binding; act as membrane or transmembrane proteins; and belong to gene clusters that are likely related to the transport and catalysis of molecules through the cell membrane and essential mechanisms of nutrient absorption. Genes with functions in cellular signaling, growth and proliferation, cell death and survival were also differentially expressed. Among the over-represented pathways were drug or xenobiotic metabolism, complement and coagulation cascades, NRF2-mediated oxidative stress, melatonin degradation and glutathione metabolism.\ud
              \ud
              \ud
                Conclusions\ud
                Our data provide new insights and perspectives on the genetic basis of feed efficiency in cattle. Some previously identified mechanisms were supported and new pathways controlling feed efficiency in Nelore cattle were discovered. We potentially identified genes and pathways that play key roles in hepatic metabolic adaptations to oxidative stress such as those involved in antioxidant mechanisms. These results improve our understanding of the metabolic mechanisms underlying feed efficiency in beef cattle and will help develop strategies for selection towards the desired phenotype

Tizioto, Polyana C

Coutinho, Luiz L

Decker, Jared E

Schnabel, Robert D

Rosa, Kamila O

Oliveira, Priscila S

Souza, Marcela M

Mourão, Gerson B

Tullio, Rymer R

Chaves, Amália S

Lanna, Dante P

Mudadu, Mauricio A

Taylor, Jeremy F

Regitano, Luciana C

Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP)

Global liver gene expression differences in Nelore steers with divergent residual feed intake phenotypes

Abstract\ud
              \ud
                Background\ud
                Efficiency of feed utilization is important for animal production because it can reduce greenhouse gas emissions and improve industry profitability. However, the genetic basis of feed utilization in livestock remains poorly understood. Recent developments in molecular genetics, such as platforms for genome-wide genotyping and sequencing, provide an opportunity to identify genes and pathways that influence production traits. It is known that transcriptional networks influence feed efficiency-related traits such as growth and energy balance. This study sought to identify differentially expressed genes in animals genetically divergent for Residual Feed Intake (RFI), using RNA sequencing methodology (RNA-seq) to obtain information from genome-wide expression profiles in the liver tissues of Nelore cattle.\ud
              \ud
              \ud
                Results\ud
                Differential gene expression analysis between high Residual Feed Intake (HRFI, inefficient) and low Residual Feed Intake (LRFI, efficient) groups was performed to provide insights into the molecular mechanisms that underlie feed efficiency-related traits in beef cattle. A total of 112 annotated genes were identified as being differentially expressed between animals with divergent RFI phenotypes. These genes are involved in ion transport and metal ion binding; act as membrane or transmembrane proteins; and belong to gene clusters that are likely related to the transport and catalysis of molecules through the cell membrane and essential mechanisms of nutrient absorption. Genes with functions in cellular signaling, growth and proliferation, cell death and survival were also differentially expressed. Among the over-represented pathways were drug or xenobiotic metabolism, complement and coagulation cascades, NRF2-mediated oxidative stress, melatonin degradation and glutathione metabolism.\ud
              \ud
              \ud
                Conclusions\ud
                Our data provide new insights and perspectives on the genetic basis of feed efficiency in cattle. Some previously identified mechanisms were supported and new pathways controlling feed efficiency in Nelore cattle were discovered. We potentially identified genes and pathways that play key roles in hepatic metabolic adaptations to oxidative stress such as those involved in antioxidant mechanisms. These results improve our understanding of the metabolic mechanisms underlying feed efficiency in beef cattle and will help develop strategies for selection towards the desired phenotype.We thank the University of Missouri for accepting the first author as a visiting\ud
scholar, the National Council for Scientific and Technological Development\ud
(CNPq) for providing financial support (grant number: 473091/2012-7) and\ud
fellowships to LLC, GBM and LCAR, and the São Paulo Research Foundation\ud
(FAPESP) for providing a scholarship to PCT (grants number: 2013/17778-4\ud
and 2014/13555-3). JFT, RDS and JED were supported by the Agriculture and\ud
Food Research Initiative competitive grant numbers: 2011-68004-30214,\ud
2011-68004-30367 and 2013-68004-20364 from the USDA National Institute\ud
of Food and Agriculture Animal Genome Program

Oliveira, Priscila SN

Lanna, Dante PD

Regitano, Luciana CA

Universidade de São Paulo

Polyana C Tizioto

Luiz L Coutinho

Jared E Decker

Robert D Schnabel

Kamila O Rosa

Priscila SN Oliveira

Marcela M Souza

Gerson B Mourão

Rymer R Tullio

Amália S Chaves

Dante PD Lanna

Adhemar Zerlotini-Neto

Mauricio A Mudadu

Jeremy F Taylor

Luciana CA Regitano

Springer - Publisher Connector

Feed efficiency-related traits are increasingly being studied because of their importance to the overall profitability of animal production

TIZIOTO, P.

COUTINHO, L. L.

DECKER, J. E.

SCHNABEL, R. D.

ROSA, K. O.

OLIVEIRA, P. S. N.

SOUZA, M. M.

MOURÃO, G. B.

TULLIO, R. R.

CHAVES, A. S.

LANNA, D. P. D.

ZERLOTINI NETO, A.

MUDADU, M. de A.

TAYLOR, J. F.

REGITANO, L. C. de A.

Repository Open Access to Scientific Information from Embrapa

Global liver gene expression differences in Nelore steers with divergent residual feed intake phenotypes.

Abstract
              
                Background
                Efficiency of feed utilization is important for animal production because it can reduce greenhouse gas emissions and improve industry profitability. However, the genetic basis of feed utilization in livestock remains poorly understood. Recent developments in molecular genetics, such as platforms for genome-wide genotyping and sequencing, provide an opportunity to identify genes and pathways that influence production traits. It is known that transcriptional networks influence feed efficiency-related traits such as growth and energy balance. This study sought to identify differentially expressed genes in animals genetically divergent for Residual Feed Intake (RFI), using RNA sequencing methodology (RNA-seq) to obtain information from genome-wide expression profiles in the liver tissues of Nelore cattle.
              
              
                Results
                Differential gene expression analysis between high Residual Feed Intake (HRFI, inefficient) and low Residual Feed Intake (LRFI, efficient) groups was performed to provide insights into the molecular mechanisms that underlie feed efficiency-related traits in beef cattle. A total of 112 annotated genes were identified as being differentially expressed between animals with divergent RFI phenotypes. These genes are involved in ion transport and metal ion binding; act as membrane or transmembrane proteins; and belong to gene clusters that are likely related to the transport and catalysis of molecules through the cell membrane and essential mechanisms of nutrient absorption. Genes with functions in cellular signaling, growth and proliferation, cell death and survival were also differentially expressed. Among the over-represented pathways were drug or xenobiotic metabolism, complement and coagulation cascades, NRF2-mediated oxidative stress, melatonin degradation and glutathione metabolism.
              
              
                Conclusions
                Our data provide new insights and perspectives on the genetic basis of feed efficiency in cattle. Some previously identified mechanisms were supported and new pathways controlling feed efficiency in Nelore cattle were discovered. We potentially identified genes and pathways that play key roles in hepatic metabolic adaptations to oxidative stress such as those involved in antioxidant mechanisms. These results improve our understanding of the metabolic mechanisms underlying feed efficiency in beef cattle and will help develop strategies for selection towards the desired phenotype

RCAAP - Repositório Científico de Acesso Aberto de Portugal

Background: Efficiency of feed utilization is important for animal production because it can reduce greenhouse gas emissions and improve industry profitability. However, the genetic basis of feed utilization in livestock remains poorly understood. Recent developments in molecular genetics, such as platforms for genome-wide genotyping and sequencing, provide an opportunity to identify genes and pathways that influence production traits. It is known that transcriptional networks influence feed efficiency-related traits such as growth and energy balance. This study sought to identify differentially expressed genes in animals genetically divergent for Residual Feed Intake (RFI), using RNA sequencing methodology (RNA-seq) to obtain information from genome-wide expression profiles in the liver tissues of Nelore cattle.Results: Differential gene expression analysis between high Residual Feed Intake (HRFI, inefficient) and low Residual Feed Intake (LRFI, efficient) groups was performed to provide insights into the molecular mechanisms that underlie feed efficiency-related traits in beef cattle. A total of 112 annotated genes were identified as being differentially expressed between animals with divergent RFI phenotypes. These genes are involved in ion transport and metal ion binding; act as membrane or transmembrane proteins; and belong to gene clusters that are likely related to the transport and catalysis of molecules through the cell membrane and essential mechanisms of nutrient absorption. Genes with functions in cellular signaling, growth and proliferation, cell death and survival were also differentially expressed. Among the over-represented pathways were drug or xenobiotic metabolism, complement and coagulation cascades, NRF2-mediated oxidative stress, melatonin degradation and glutathione metabolism.Conclusions: Our data provide new insights and perspectives on the genetic basis of feed efficiency in cattle. Some previously identified mechanisms were supported and new pathways controlling feed efficiency in Nelore cattle were discovered. We potentially identified genes and pathways that play key roles in hepatic metabolic adaptations to oxidative stress such as those involved in antioxidant mechanisms. These results improve our understanding of the metabolic mechanisms underlying feed efficiency in beef cattle and will help develop strategies for selection towards the desired phenotype.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP

Rosa, Kamila de Oliveira

Acervo Digital da Unesp

file:///data/remote/core/dit/data/Springer-OA/pdf/c83/aHR0cDovL2xpbmsuc3ByaW5nZXIuY29tLzEwLjExODYvczEyODY0LTAxNS0xNDY0LXgucGRm.pdf