La presente invención se refiere a una familia de

benzotialoles diferentemente sustituidos que

presentan actividad inhibitoria de la enzima caseína

quinasa 1 (CK-1), por lo que son útiles para el

tratamiento o prevención de enfermedades mediadas

por esta enzima, especialmente, enfermedades

relacionadas con el ritmo circadiano, enfermedades

inflamatorias, autoinmunes, psiquiátricas,

neurodegenerativas, neurológicas, oftalmológicas, así

como para inducir regeneración celularPeer reviewedConsejo Superior de Investigaciones CientíficasB1 Patente sin examen previ

Italiano, Claire Marie

Kamarulzaman, Adeeba

Kong, David Chee Ming

Lai, Pauline Siew Mei

Lim, Mun Kit

Omar, Sharifah Faridah Syed

Ponnampalavanar, Sasheela Sri La Sri

Taib, Nur Aishah

Yusof, Mohamad Yasim

Journal of Infection in Developing Countries

Lim, Mun

Lai, Pauline

Ponnampalavanar, Sasheela

Omar, Sharifah

Taib, Nur

Yusof, Mohamad

Italiano, Claire

Kong, David

Monash University Research Repository

Antibiotics in surgical wards: use or misuse? A newly industrialized country's perspective

Introduction: Studies exploring the appropriateness of therapeutic antibiotic use among surgical patients are limited, particularly in developing countries. Therefore, the aim of our study was to determine the appropriateness of antibiotics prescribed in a surgical setting in Malaysia. Methodology: A prospective observational study was conducted in two surgical wards at a tertiary hospital in Malaysia from November 2012-July 2013. Data was collected using a case report form. The appropriateness of antibiotic therapy was based on compliance with either the Malaysian National Antibiotic Guidelines 2008 or International Clinical Practice Guidelines and determined by an expert panel (consisting of two infectious disease consultants and a pharmacist). Results: Over the study period, a total of 593 antibiotic courses were prescribed for 129 patients (4.6±3.4 antibiotics/patient). Only 34 (26.4%) patients received appropriate antibiotic therapy, whilst 95 (73.6%) patients received at least one course of inappropriate antibiotic therapy. The prevalence of inappropriate antibiotic use was 214 (66.3%) and 55 (42.0%) for prophylactic and therapeutic purposes, respectively. The most common causes of inappropriate prophylactic antibiotics were inappropriate timing 20 (36.4%) and inappropriate duration of prophylaxis 19 (34.5%). In cases of inappropriate timing, 9 (45%) were administered too late while 6 (30%) were too early. . In contrast, inappropriate choice of antibiotics (42.1%) and inappropriate indication (40.7%) were the most common reasons encountered for inappropriate therapeutic antibiotics. Conclusion: Our study suggests considerable inappropriate use of both prophylactic and therapeutic antibiotics in the surgical wards; highlighting an urgent need for antibiotic stewardship initiatives in this setting.</jats:p

Mun Kit Lim

Pauline Siew Mei Lai

Sasheela Sri La Sri Ponnampalavanar

Sharifah Faridah Syed Omar

Nur Aishah Taib

Mohamad Yasim Yusof

Claire Marie Italiano

David Chee Ming Kong

Adeeba Kamarulzaman

Crossref

The Journal of Infection in Developing Countries

Antibiotics in surgical wards: use or misuse? A newly industrialized country’s perspective

La presente invención se refiere a una familia de
benzotialoles diferentemente sustituidos que
presentan actividad inhibitoria de la enzima caseína
quinasa 1 (CK-1), por lo que son útiles para el
tratamiento o prevención de enfermedades mediadas
por esta enzima, especialmente, enfermedades
relacionadas con el ritmo circadiano, enfermedades
inflamatorias, autoinmunes, psiquiátricas,
neurodegenerativas, neurológicas, oftalmológicas, así
como para inducir regeneración celularPeer reviewedConsejo Superior de Investigaciones CientíficasB1 Patente sin examen previ

Martínez Gil, Ana

Pérez, Daniel I.

Gil, Carmen

García Salado, Irene

Redondo, Miriam

Pérez, Concepción

Digital.CSIC

Benzotiazoles sustituidos y sus aplicaciones terapéuticas para el tratamiento de enfermedades humanas

Introduction: Studies exploring the appropriateness of therapeutic antibiotic use among surgical patients are limited, particularly in developing countries. Therefore, the aim of our study was to determine the appropriateness of antibiotics prescribed in a surgical setting in Malaysia.
 Methodology: A prospective observational study was conducted in two surgical wards at a tertiary hospital in Malaysia from November 2012-July 2013. Data was collected using a case report form. The appropriateness of antibiotic therapy was based on compliance with either the Malaysian National Antibiotic Guidelines 2008 or International Clinical Practice Guidelines and determined by an expert panel (consisting of two infectious disease consultants and a pharmacist).
 Results: Over the study period, a total of 593 antibiotic courses were prescribed for 129 patients (4.6±3.4 antibiotics/patient). Only 34 (26.4%) patients received appropriate antibiotic therapy, whilst 95 (73.6%) patients received at least one course of inappropriate antibiotic therapy. The prevalence of inappropriate antibiotic use was 214 (66.3%) and 55 (42.0%) for prophylactic and therapeutic purposes, respectively. The most common causes of inappropriate prophylactic antibiotics were inappropriate timing 20 (36.4%) and inappropriate duration of prophylaxis 19 (34.5%). In cases of inappropriate timing, 9 (45%) were administered too late while 6 (30%) were too early. . In contrast, inappropriate choice of antibiotics (42.1%) and inappropriate indication (40.7%) were the most common reasons encountered for inappropriate therapeutic antibiotics.
 Conclusion: Our study suggests considerable inappropriate use of both prophylactic and therapeutic antibiotics in the surgical wards; highlighting an urgent need for antibiotic stewardship initiatives in this setting

Directory of Open Access Journals

Introduction: Studies exploring the appropriateness of therapeutic antibiotic use among surgical patients are limited, particularly in developing countries. Therefore, the aim of our study was to determine the appropriateness of antibiotics prescribed in a surgical setting in Malaysia. Methodology: A prospective observational study was conducted in two surgical wards at a tertiary hospital in Malaysia from November 2012-July 2013. Data was collected using a case report form. The appropriateness of antibiotic therapy was based on compliance with either the Malaysian National Antibiotic Guidelines 2008 or International Clinical Practice Guidelines and determined by an expert panel (consisting of two infectious disease consultants and a pharmacist). Results: Over the study period, a total of 593 antibiotic courses were prescribed for 129 patients (4.6±3.4 antibiotics/patient). Only 34 (26.4%) patients received appropriate antibiotic therapy, whilst 95 (73.6%) patients received at least one course of inappropriate antibiotic therapy. The prevalence of inappropriate antibiotic use was 214 (66.3%) and 55 (42.0%) for prophylactic and therapeutic purposes, respectively. The most common causes of inappropriate prophylactic antibiotics were inappropriate timing 20 (36.4%) and inappropriate duration of prophylaxis 19 (34.5%). In cases of inappropriate timing, 9 (45%) were administered too late while 6 (30%) were too early.. In contrast, inappropriate choice of antibiotics (42.1%) and inappropriate indication (40.7%) were the most common reasons encountered for inappropriate therapeutic antibiotics. Conclusion: Our study suggests considerable inappropriate use of both prophylactic and therapeutic antibiotics in the surgical wards; highlighting an urgent need for antibiotic stewardship initiatives in this setting

Monash University Research Portal

English

https://jidc.org/index.php/journal/article/download/26623636/1420

Benzotiazoles sustituidos y sus aplicaciones terapéuticas para el tratamiento de enfermedades humanas

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Monash University Research Repository

Crossref

Digital.CSIC

Directory of Open Access Journals

Monash University Research Portal