Bone marrow adipose tissue (MAT) contains a fat depot of unknown function. Characterization of this tissue in healthy and pathophysiological conditions may be an important step in order to understand MAT contribution to development of osteoporosis and perhaps to develop means to improve bone health by manipulation with a phenotype of MAT. Here we demonstrate that MAT, brown adipose tissue (BAT), and white adipose tissue (WAT) derived from healthy mice differ in fatty acid and phospholipid composition. The profile of MAT changed to resemble a less-metabolically active tissue upon metabolic impairment as seen in diet-induced obesity. Additionally, PPARγ activation alters MAT to be become more BAT-like, and the lipid profile and bone marrow environment can be improved with a selective and partial PPARγ agonist such as the test drug SRI0171 Hence it is possible to pharmacologically manipulate the lipid environment in bone marrow
