In terms of the diversity of quinolines, 2,4-dichloro compounds can play a role as key
intermediates in synthesis of 2,4-disubstituted quinolines by possible stepwise substitution at
C4 and C2 positions, where the chance for study of regioselectivity is more. This obvious
significance prompted us to study the selectivity referred to 2,4-dichloroquinolines, in which
one of the chlorine is selectively replaced under controlled temperature to yield new
molecular structures with high pharmacological importance or with interesting properties
