New sequencing technology has enabled the identification of thousands of single nucleotide polymorphisms in the exome, and many computational and statistical approaches to identify disease-association signals have emerged.National Institutes of Health (U.S.) (Grant R01-MH084676)National Institutes of Health (U.S.) (Grant R01-GM078598)National Institutes of Health (U.S.) (Training grant T32-HL07604-25)Brigham and Women's Hospital (Division of Cardiovascular Medicine