Computational and statistical approaches to analyzing variants identified by exome sequencing

Abstract

New sequencing technology has enabled the identification of thousands of single nucleotide polymorphisms in the exome, and many computational and statistical approaches to identify disease-association signals have emerged.National Institutes of Health (U.S.) (Grant R01-MH084676)National Institutes of Health (U.S.) (Grant R01-GM078598)National Institutes of Health (U.S.) (Training grant T32-HL07604-25)Brigham and Women's Hospital (Division of Cardiovascular Medicine