Материалы XII Междунар. науч. конф. студентов, магистрантов, аспирантов и молодых ученых, Гомель, 16–17 мая 2019 г

Andres Metspalu

Annette Peters

Arnulf Langhammer

BM Knoppers

Christian Gieger

Claes Ladenvall

CM Hamilton

Cornelia M van Duijn

Dorret I Boomsma

Eco JC de Geus

G Olund

Gonneke Willemsen

Huei-Yi Shen

I Budin-Ljøsne

I Fortier

Inga Prokopenko

Isabel Fortier

J Kaiser

J Karvanen

J Malone

Jan-Eric Litton

Jani Heikkinen

Janina S Ried

Janis Klovins

Janna Hastings

Jennifer R Harris

Joern Dietrich

Johan Rung

Jon Heggland

Jouke-Jan Hottenga

JP Vandenbroucke

JR Harris

Juha Karvanen

Juni Palmgren

Kristian Hveem

L Emilsson

L Norlin

Leif Groop

Linda Zaharenko

M Ashburner

M Gostev

Maria Krestyaninova

Mark I McCarthy

Mats-Åke Persson

MD Mailman

Melanie Waldenberger

MI McCarthy

MJ Knol

Nancy L Pedersen

Ola Spjuth

PN Robinson

Samuli Ripatti

Sandra Ose

TA Manolio

Tõnu Esko

European Journal of Human Genetics

PubMed

Асвинов, Р. В.

Electronic Library Pavel Sukhoi State Technical University of Gomel (GSTU)

Совершенствование технологий для осуществления рентабельного процесса добычи нефти на малодебитном фонде скважин

Spjuth, O

Krestyaninova, M

Hastings, J

Shen, HY

Heikkinen, J

Waldenberger, M

Langhammer, A

Ladenvall, C

Esko, T

Persson, M A

Heggland, J

Dietrich, J

Ose, S

Gieger, C

Ried, JS

Peters, A

Fortier, I

de Geus, EJC

Klovins, J

Zaharenko, L

Willemsen, G

Hottenga, JJ

Litton, JE

Karvanen, J

Boomsma, DI

Groop, L

Rung, J

Palmgren, J

Pedersen, NL

McCarthy, MI

Duijn, Cornelia

Hveem, K

Metspalu, A

Ripatti, S

Prokopenko, I

Harris, JR

NARCIS 

Harmonising and linking biomedical and clinical data across disparate data archives to enable integrative cross-biobank research

A wealth of biospecimen samples are stored in modern globally distributed biobanks. Biomedical researchers worldwide need to be able to combine the available resources to improve the power of large-scale studies. A prerequisite for this effort is to be able to search and access phenotypic, clinical and other information about samples that are currently stored at biobanks in an integrated manner. However, privacy issues together with heterogeneous information systems and the lack of agreed-upon vocabularies have made specimen searching across multiple biobanks extremely challenging. We describe three case studies where we have linked samples and sample descriptions in order to facilitate global searching of available samples for research. The use cases include the ENGAGE (European Network for Genetic and Genomic Epidemiology) consortium comprising at least 39 cohorts, the SUMMIT (surrogate markers for micro- and macro-vascular hard endpoints for innovative diabetes tools) consortium and a pilot for data integration between a Swedish clinical health registry and a biobank. We used the Sample avAILability (SAIL) method for data linking: first, created harmonised variables and then annotated and made searchable information on the number of specimens available in individual biobanks for various phenotypic categories. By operating on this categorised availability data we sidestep many obstacles related to privacy that arise when handling real values and show that harmonised and annotated records about data availability across disparate biomedical archives provide a key methodological advance in pre-analysis exchange of information between biobanks, that is, during the project planning phase.European Journal of Human Genetics advance online publication, 26 August 2015; doi:10.1038/ejhg.2015.165

Persson, M

de Geus, EJ

van Duijn, CM

Spiral - Imperial College Digital Repository

Harmonising and linking biomedical and clinical data across disparate data archives to enable integrative cross-biobank research.

Spjuth, Ola

Krestyaninova, Maria

Hastings, Janna

Shen, Huei-Yi

Heikkinen, Jani

Waldenberger, Melanie

Langhammer, Arnulf

Ladenvall, Claes,

Esko, Tõnu

Persson, Mats-Åke,

Heggland, Jon

Dietrich, Joern

Ose, Sandra

Gieger, Christian

Ried, Janina S

Peters, Annette

Fortier, Isabel

de Geus, Eco Jc

Klovins, Janis

Zaharenko, Linda

Willemsen, Gonneke

Hottenga, Jouke-Jan

Litton, Jan-Eric

Karvanen, Juha

Boomsma, Dorret I

Groop, Leif,

Rung, Johan

Palmgren, Juni

Pedersen, Nancy L

McCarthy, Mark I

van Duijn, Cornelia M

Hveem, Kristian

Metspalu, Andres

Ripatti, Samuli

Prokopenko, Inga

Harris, Jennifer R

Lund University.

Swepub

Harmonising and linking biomedical and clinical data across disparate data archives to enable integrative cross-biobank research. [Elektronisk resurs]

EUR Research Repository

English

A wealth of biospecimen samples are stored in modern globally distributed biobanks. Biomedical researchers worldwide need to
be able to combine the available resources to improve the power of large-scale studies. A prerequisite for this effort is to be able
to search and access phenotypic, clinical and other information about samples that are currently stored at biobanks in an
integrated manner. However, privacy issues together with heterogeneous information systems and the lack of agreed-upon
vocabularies have made specimen searching across multiple biobanks extremely challenging. We describe three case studies
where we have linked samples and sample descriptions in order to facilitate global searching of available samples for research.
The use cases include the ENGAGE (European Network for Genetic and Genomic Epidemiology) consortium comprising at least
39 cohorts, the SUMMIT (surrogate markers for micro- and macro-vascular hard endpoints for innovative diabetes tools)
consortium and a pilot for data integration between a Swedish clinical health registry and a biobank. We used the Sample
avAILability (SAIL) method for data linking: first, created harmonised variables and then annotated and made searchable
information on the number of specimens available in individual biobanks for various phenotypic categories. By operating on this
categorised availability data we sidestep many obstacles related to privacy that arise when handling real values and show that
harmonised and annotated records about data availability across disparate biomedical archives provide a key methodological
advance in pre-analysis exchange of information between biobanks, that is, during the project planning phase

Harris, Jennifer

Ladenvall, Claes

Persson, Mats-Åke

Ried, Janina S.

de Geus, Eco JC

Groop, Leif

NORA - Norwegian Open Research Archives

https://ntnuopen.ntnu.no/ntnu-xmlui/bitstream/11250/2388239/3/Spjuth_2015_Har.pdf

Совершенствование технологий для осуществления рентабельного процесса добычи нефти на малодебитном фонде скважин

Abstract

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Electronic Library Pavel Sukhoi State Technical University of Gomel (GSTU)

NARCIS

Spiral - Imperial College Digital Repository

Swepub

EUR Research Repository

EUR Research Repository

NORA - Norwegian Open Research Archives