МЕДИЦИНСКИЕ ИНСТИТУТЫОБУЧЕНИ

A Kurioka

A Pawlowski

Abdul W. Ansari

Adeeba Kamarulzaman

Alireza Saeidi

C Cosgrove

C Geldmacher

C Lecureuil

CL Day

CS Fernandez

D Greenspan

Devi V. Rukumani

DR Chung

E Billerbeck

E Leeansyah

E Martin

EA Berger

EB Wong

EM Shankar

Esaki M. Shankar

Haider A. Al-Darraji

Hong Y. Tan

J Jiang

JE Ussher

JF Djoba Siawaya

Johan K. Sandberg

JR Carlyle

JR Fergusson

L Le Bourhis

L Maggi

L Trautmann

LJ Walker

LL Lanier

M Dusseaux

Marie Larsson

MC Gold

Muttiah Barathan

P Sonnenberg

R Reantragoon

R Sutherland

Rami Al-Batran

S Brand

S Huang

Sasheela Ponnampalavanar

Vicky L. Tien Tien

Vijayakumar Velu

Yean K. Yong

PLoS ONE

PubMed

Беляева, Л. Е.

Шебеко, В. И.

Electronic arhive of Vitebsk State Medical University Library  (Репозиторий библиотеки Витебского государственного медицинского университета)

Результаты внедрения новой формы управляемой самостоятельной работы студентов в учебный процесс на кафедре патофизиологии

Mucosal-associated invariant T (MAIT) cells are evolutionarily conserved antimicrobial MR1-restricted CD8+ T cells co-expressing the semi-invariant TCR V alpha 7.2, and are numerous in the blood and mucosal tissues of humans. MAIT cells appear to undergo exhaustion in chronic viral infections. However, their role in human immunodeficiency virus type 1 (HIV1) mono-infection and HIV/tuberculosis (TB) co-infection have seldom been elaborately investigated. We conducted a cross-sectional study to investigate the frequencies and phenotypes of CD161++ CD8+ T cells among anti-retroviral therapy (ART)/anti-TB therapy (ATT) treatment-naive HIV/TB co-infected, ART/TB treated HIV/TB co-infected, ART naive HIV-infected, ART-treated HIV-infected patients, and HIV negative healthy controls (HCs) by flow cytometry. Our data revealed that the frequency of MAIT cells was severely depleted in HIV mono-and HIV/TB co-infections. Further, PD-1 expression on MAIT cells was significantly increased in HIV mono-and HIV-TB co-infected patients. The frequency of MAIT cells did not show any significant increase despite the initiation of ART and/or ATT. Majority of the MAIT cells in HCs showed a significant increase in CCR6 expression as compared to HIV/TB co-infections. No marked difference was seen with expressions of chemokine co-receptor CCR5 and CD103 among the study groups. Decrease of CCR6 expression appears to explain why HIV-infected patients display weakened mucosal immune responses.Funding Agencies|High Impact Research [UM.C/625/1/HIR/MOHE/MED/014]; University of Malaya Research of the Health and Translational Medicine Research Cluster [RP021A-13HTM, RG448-12HTM]; Swedish Research Council [AI52731]; Swedish Physicians against AIDS Research Foundation; Swedish International Development Cooperation Agency; SIDA SARC; VINNMER for Vinnova; Linkoping University Hospital Research Fund; CALF; Swedish Society of Medicine</p

Saeidi, Alireza

Tien Tien, Vicky L.

Al-Batran, Rami

Al-Darraji, Haider A.

Tan, Hong Y.

Yong, Yean K.

Ponnampalavanar, Sasheela

Barathan, Muttiah

Rukumani, Devi V.

Ansari, Abdul W.

Velu, Vijayakumar

Kamarulzaman, Adeeba

Larsson, Marie

Shankar, Esaki M.

Digitala Vetenskapliga Arkivet - Academic Archive On-line

Attrition of TCR Va7.2+CD161++ MAIT Cells in HIV-Tuberculosis Co-Infection Is Associated with Elevated Levels of PD-1 Expression

Academic Archive On-line (Linköping University, Sweden)

Mucosal-associated invariant T (MAIT) cells are evolutionarily conserved antimicrobial MR1-restricted CD8(+) T cells co-expressing the semi-invariant TCR Vα7.2, and are numerous in the blood and mucosal tissues of humans. MAIT cells appear to undergo exhaustion in chronic viral infections. However, their role in human immunodeficiency virus type 1 (HIV-1) mono-infection and HIV/tuberculosis (TB) co-infection have seldom been elaborately investigated. We conducted a cross-sectional study to investigate the frequencies and phenotypes of CD161(++)CD8(+) T cells among anti-retroviral therapy (ART)/anti-TB therapy (ATT) treatment-naïve HIV/TB co-infected, ART/TB treated HIV/TB co-infected, ART naïve HIV-infected, ART-treated HIV-infected patients, and HIV negative healthy controls (HCs) by flow cytometry. Our data revealed that the frequency of MAIT cells was severely depleted in HIV mono- and HIV/TB co-infections. Further, PD-1 expression on MAIT cells was significantly increased in HIV mono- and HIV-TB co-infected patients. The frequency of MAIT cells did not show any significant increase despite the initiation of ART and/or ATT. Majority of the MAIT cells in HCs showed a significant increase in CCR6 expression as compared to HIV/TB co-infections. No marked difference was seen with expressions of chemokine co-receptor CCR5 and CD103 among the study groups. Decrease of CCR6 expression appears to explain why HIV-infected patients display weakened mucosal immune responses

Vicky L Tien Tien

Haider A Al-Darraji

Hong Y Tan

Yean K Yong

Devi V Rukumani

Abdul W Ansari

Esaki M Shankar

Directory of Open Access Journals

Attrition of TCR Vα7.2+ CD161++ MAIT cells in HIV-tuberculosis co-infection is associated with elevated levels of PD-1 expression.

Publikationer från Linköpings universitet

Crossref

Attrition of TCR Vα7.2+ CD161++ MAIT Cells in HIV-Tuberculosis Co-Infection Is Associated with Elevated Levels of PD-1 Expression

http://elib.vsmu.by/bitstream/handle/123/8371/vVGMU_2010_2_171-176.pdf?sequence=1&isAllowed=y

Результаты внедрения новой формы управляемой самостоятельной работы студентов в учебный процесс на кафедре патофизиологии

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Electronic arhive of Vitebsk State Medical University Library (Репозиторий библиотеки Витебского государственного медицинского университета)

Digitala Vetenskapliga Arkivet - Academic Archive On-line

Academic Archive On-line (Linköping University, Sweden)

Directory of Open Access Journals

Publikationer från Linköpings universitet

Crossref