КИШЕЧНАЯ НЕПРОХОДИМОСТЬПЕРИТОНИТТОЛСТАЯ КИШК

Денисенко, В. Л.

Гаин, Ю. М.

Шахрай, С. В.

Веремей, Э. И.

Журба, В. А.

Рукаль, В. М.

Гаин, М. Ю.

Helmersson-Karlqvist, J

Arnlov, J

Carlsson, AC

harma, J

Larsson, A

Swepub

Increased urinary cystatin C indicated higher risk of cardiovascular death in a community cohort

Electronic arhive of Vitebsk State Medical University Library  (Репозиторий библиотеки Витебского государственного медицинского университета)

Моделирование обтурационной толстокишечной непроходимости у лабораторных животных

OBJECTIVES: Urinary cystatin C (u-CysC) is a new biomarker for acute tubular kidney dysfunction and may also indicate chronic tubular dysfunction. Chronic kidney disease is an important cardiovascular risk factor, however it is not known if u-CysC is a risk marker for cardiovascular death. METHODS: The association between u-CysC and cardiovascular mortality was investigated in a Swedish community-based cohort of 604 men aged 78 years. During follow-up (mean 6.7 years), 203 participants died, of which 90 due to cardiovascular causes. RESULTS: High u-CysC (&gt;0.029 mg/mmol Cr) was associated with a more than 2-fold risk of cardiovascular death (multivariable hazard ratio for quintile 5 vs. 1: 2.5, 95% CI 1.2-5.2, P &lt; 0.05) in Cox regression models independent of cardiovascular risk factors, glomerular filtration rate (eGFR) and urinary Albumin. Participants with low eGFR (≤60 mL/min), albuminuria (≥3 mg/mmol Cr) and high u-CysC (&gt;0.029 mg/mmol Cr) combined had a significantly higher cardiovascular mortality risk compared to participants with one or two of these biomarkers normal (hazard ratio 15, 95% CI: 6.7-36, P &lt; 0.001, compared to all three biomarkers normal). CONCLUSIONS: This study is the first to show that increased concentrations of the tubular kidney biomarker u-CysC indicated risk of cardiovascular death independently of other cardiovascular risk factors, glomerular filtration and albuminuria. Additional research is needed to further establish the usefulness of u-CysC in clinical practice

Helmersson-Karlqvist, Johanna

Ärnlöv, Johan

Carlsson, Axel C

Härmä, Johan

Larsson, Anders

Name not available

OBJECTIVES: Urinary cystatin C (u-CysC) is a new biomarker for acute tubular kidney dysfunction and may also indicate chronic tubular dysfunction. Chronic kidney disease is an important cardiovascular risk factor, however it is not known if u-CysC is a risk marker for cardiovascular death.METHODS: The association between u-CysC and cardiovascular mortality was investigated in a Swedish community-based cohort of 604 men aged 78 years. During follow-up (mean 6.7 years), 203 participants died, of which 90 due to cardiovascular causes.RESULTS: High u-CysC (&gt;0.029 mg/mmol Cr) was associated with a more than 2-fold risk of cardiovascular death (multivariable hazard ratio for quintile 5 vs. 1: 2.5, 95% CI 1.2-5.2, P &lt; 0.05) in Cox regression models independent of cardiovascular risk factors, glomerular filtration rate (eGFR) and urinary Albumin. Participants with low eGFR (≤60 mL/min), albuminuria (≥3 mg/mmol Cr) and high u-CysC (&gt;0.029 mg/mmol Cr) combined had a significantly higher cardiovascular mortality risk compared to participants with one or two of these biomarkers normal (hazard ratio 15, 95% CI: 6.7-36, P &lt; 0.001, compared to all three biomarkers normal).CONCLUSIONS: This study is the first to show that increased concentrations of the tubular kidney biomarker u-CysC indicated risk of cardiovascular death independently of other cardiovascular risk factors, glomerular filtration and albuminuria. Additional research is needed to further establish the usefulness of u-CysC in clinical practice.</p

Helmersson-Karlqvist, Johanna,

Ärnlöv, Johan,

Carlsson, Axel C,

Härmä, Johan,

Larsson, Anders,

Increased urinary cystatin C indicated higher risk of cardiovascular death in a community cohort [Elektronisk resurs]

Johanna Helmersson-Karlqvist

Johan Ärnlöv

Axel C. Carlsson

Johan Härmä

Anders Larsson

Crossref

Atherosclerosis

OBJECTIVES: Urinary cystatin C (u-CysC) is a new biomarker for acute tubular kidney dysfunction and may also indicate chronic tubular dysfunction. Chronic kidney disease is an important cardiovascular risk factor, however it is not known if u-CysC is a risk marker for cardiovascular death.METHODS: The association between u-CysC and cardiovascular mortality was investigated in a Swedish community-based cohort of 604 men aged 78 years. During follow-up (mean 6.7 years), 203 participants died, of which 90 due to cardiovascular causes.RESULTS: High u-CysC (&gt;0.029 mg/mmol Cr) was associated with a more than 2-fold risk of cardiovascular death (multivariable hazard ratio for quintile 5 vs. 1: 2.5, 95% CI 1.2-5.2, P &lt; 0.05) in Cox regression models independent of cardiovascular risk factors, glomerular filtration rate (eGFR) and urinary Albumin. Participants with low eGFR (≤60 mL/min), albuminuria (≥3 mg/mmol Cr) and high u-CysC (&gt;0.029 mg/mmol Cr) combined had a significantly higher cardiovascular mortality risk compared to participants with one or two of these biomarkers normal (hazard ratio 15, 95% CI: 6.7-36, P &lt; 0.001, compared to all three biomarkers normal).CONCLUSIONS: This study is the first to show that increased concentrations of the tubular kidney biomarker u-CysC indicated risk of cardiovascular death independently of other cardiovascular risk factors, glomerular filtration and albuminuria. Additional research is needed to further establish the usefulness of u-CysC in clinical practice.</p

Publikationer från Uppsala Universitet

Digitala Vetenskapliga Arkivet - Academic Archive On-line

http://elib.vsmu.by/bitstream/handle/123/7834/vVGMU_2011_1_25-32.pdf?sequence=1&isAllowed=y

Моделирование обтурационной толстокишечной непроходимости у лабораторных животных

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Electronic arhive of Vitebsk State Medical University Library (Репозиторий библиотеки Витебского государственного медицинского университета)

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Crossref

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Publikationer från Uppsala Universitet

Digitala Vetenskapliga Arkivet - Academic Archive On-line