АЛЛОТРАНСПЛАНТАЦИЯГИПОПАРАТИРЕОЗИММУНОСУПРЕССИЯПАРАЩИТОВИДНЫЕ ЖЕЛЕЗЫ /хирТКАНЕВАЯ ТЕРАПИ

Aeinehband, Shahin

Al Nimer, Faiez

Darreh-Shori, Taher

Khademi, Mohsen

Lindblom, Rickard P F

Nilsson, Bo

Nilsson, Kristina Ekdahl

Olsson, Tomas

Piehl, Fredrik

Sandholm, Kerstin

Vijayaraghavan, Swetha

PubMed

Dysregulation of the complement system is evident in many CNS diseases but mechanisms regulating complement activation in the CNS remain unclear. In a recent large rat genomewide expression profiling and linkage analysis we found co-regulation of complement C3 immediately downstream of butyrylcholinesterase (BuChE), an enzyme hydrolyzing acetylcholine (ACh), a classical neurotransmitter with immunoregulatory effects. We here determined levels of neurofilament-light (NFL), a marker for ongoing nerve injury, C3 and activity of the two main ACh hydrolyzing enzymes, acetylcholinesterase (AChE) and BuChE, in cerebrospinal fluid (CSF) from patients with MS (n = 48) and non-inflammatory controls (n = 18). C3 levels were elevated in MS patients compared to controls and correlated both to disability and NFL. C3 levels were not induced by relapses, but were increased in patients with &gt;= 9 cerebral lesions on magnetic resonance imaging and in patients with progressive disease. BuChE activity did not differ at the group level, but was correlated to both C3 and NFL levels in individual samples. In conclusion, we show that CSF C3 correlates both to a marker for ongoing nerve injury and degree of disease disability. Moreover, our results also suggest a potential link between intrathecal cholinergic activity and complement activation. These results motivate further efforts directed at elucidating the regulation and effector functions of the complement system in MS, and its relation to cholinergic tone.</p

Aeinehband, Shahin,

Lindblom, Rickard P. F.,

Al Nimer, Faiez,

Vijayaraghavan, Swetha,

Sandholm, Kerstin,

Khademi, Mohsen,

Olsson, Tomas,

Nilsson, Bo,

Nilsson Ekdahl, Kristina,

Darreh-Shori, Taher,

Piehl, Fredrik,

Swepub

Complement Component C3 and Butyrylcholinesterase Activity Are Associated with Neurodegeneration and Clinical Disability in Multiple Sclerosis

Хрыщанович, В. Я.

Третьяк, С. И.

Харламова, А. Н.

Кондратович, В. А.

Писаренко, А. М.

Кузьменков, Е. И.

Романович, А. В.

Большов, А. В.

Electronic arhive of Vitebsk State Medical University Library  (Репозиторий библиотеки Витебского государственного медицинского университета)

Результаты паратиреоидной аллотрансплантации

Dysregulation of the complement system is evident in many CNS diseases but mechanisms regulating complement activation in the CNS remain unclear. In a recent large rat genomewide expression profiling and linkage analysis we found co-regulation of complement C3 immediately downstream of butyrylcholinesterase (BuChE), an enzyme hydrolyzing acetylcholine (ACh), a classical neurotransmitter with immunoregulatory effects. We here determined levels of neurofilament-light (NFL), a marker for ongoing nerve injury, C3 and activity of the two main ACh hydrolyzing enzymes, acetylcholinesterase (AChE) and BuChE, in cerebrospinal fluid (CSF) from patients with MS (n = 48) and non-inflammatory controls (n = 18). C3 levels were elevated in MS patients compared to controls and correlated both to disability and NFL. C3 levels were not induced by relapses, but were increased in patients with &gt;= 9 cerebral lesions on magnetic resonance imaging and in patients with progressive disease. BuChE activity did not differ at the group level, but was correlated to both C3 and NFL levels in individual samples. In conclusion, we show that CSF C3 correlates both to a marker for ongoing nerve injury and degree of disease disability. Moreover, our results also suggest a potential link between intrathecal cholinergic activity and complement activation. These results motivate further efforts directed at elucidating the regulation and effector functions of the complement system in MS, and its relation to cholinergic tone

Publikationer från Uppsala Universitet

Name not available

Shahin Aeinehband

Rickard P. F. Lindblom

Faiez Al Nimer

Swetha Vijayaraghavan

Kerstin Sandholm

Mohsen Khademi

Tomas Olsson

Bo Nilsson

Kristina Nilsson Ekdahl

Taher Darreh-Shori

Fredrik Piehl

Crossref

PLoS ONE

Dysregulation of the complement system is evident in many CNS diseases but mechanisms regulating complement activation in the CNS remain unclear. In a recent large rat genome-wide expression profiling and linkage analysis we found co-regulation of complement C3 immediately downstream of butyrylcholinesterase (BuChE), an enzyme hydrolyzing acetylcholine (ACh), a classical neurotransmitter with immunoregulatory effects. We here determined levels of neurofilament-light (NFL), a marker for ongoing nerve injury, C3 and activity of the two main ACh hydrolyzing enzymes, acetylcholinesterase (AChE) and BuChE, in cerebrospinal fluid (CSF) from patients with MS (n = 48) and non-inflammatory controls (n = 18). C3 levels were elevated in MS patients compared to controls and correlated both to disability and NFL. C3 levels were not induced by relapses, but were increased in patients with ≥9 cerebral lesions on magnetic resonance imaging and in patients with progressive disease. BuChE activity did not differ at the group level, but was correlated to both C3 and NFL levels in individual samples. In conclusion, we show that CSF C3 correlates both to a marker for ongoing nerve injury and degree of disease disability. Moreover, our results also suggest a potential link between intrathecal cholinergic activity and complement activation. These results motivate further efforts directed at elucidating the regulation and effector functions of the complement system in MS, and its relation to cholinergic tone

Rickard P F Lindblom

Directory of Open Access Journals

Complement component C3 and butyrylcholinesterase activity are associated with neurodegeneration and clinical disability in multiple sclerosis.

Digitala Vetenskapliga Arkivet - Academic Archive On-line

Результаты паратиреоидной аллотрансплантации

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