After a general examination of Rule 10b-5 in the context of its traditional application, this comment focuses on the recent developments concerning the rule\u27s function as a weapon for the enforcement of controlling insiders\u27 duties to their corporation

Caidahl, Kenneth

D’hooge, Jan

Heyde, Brecht

Larsson, Matilda

Widman, Erik

English

Current clinical ultrasound-based methods for plaque characterization are limited to visual assessment of plaque echogenicity creating demand for quantitative diagnostic tools. Our objective was to validate radial and longitudinal speckle tracking (ST) strain in phantom plaques via sonomicrometry (sono), and to compare the peak plaque and arterial wall strain. Four carotid artery gel-phantoms with a soft wall inclusion, mimicking a vulnerable plaque, were constructed. The phantoms were connected to a programmable pump simulating a carotid flow. Cineloops were acquired using a GE Vivid E9 where radial and longitudinal strain were calculated using a normalized cross-correlation ST algorithm. The region of interest was adjusted according to the plaque size. Sonomicrometry was used as a reference measurement. The correlation between estimated mean peak strain and the reference peak strain was r = 0.96 (p &lt; 0.001) radially and r = 0.75 (p ≤ 0.005) longitudinally. The soft plaque exhibited 35.1% (SD 16.9%) greater radial (p &lt; 0.001) and 88.6% (SD 72.0%) greater longitudinal (p &lt; 0.001) peak strain than the arterial wall when measured with speckle tracking. It was possible to estimate plaque strain by ST and to distinguish a soft plaque from the vessel wall via strain measurements.QC 20140103</p

Academic Archive On-line (KTH, Sweden)

Speckle tracking strain estimation of a carotid artery plaque phantom - Validation via sonomicrometry

Current clinical ultrasound-based methods for plaque characterization are limited to visual assessment of plaque echogenicity creating demand for quantitative diagnostic tools. Our objective was to validate radial and longitudinal speckle tracking (ST) strain in phantom plaques via sonomicrometry (sono), and to compare the peak plaque and arterial wall strain. Four carotid artery gel-phantoms with a soft wall inclusion, mimicking a vulnerable plaque, were constructed. The phantoms were connected to a programmable pump simulating a carotid flow. Cineloops were acquired using a GE Vivid E9 where radial and longitudinal strain were calculated using a normalized cross-correlation ST algorithm. The region of interest was adjusted according to the plaque size. Sonomicrometry was used as a reference measurement. The correlation between estimated mean peak strain and the reference peak strain was r = 0.96 (p &lt; 0.001) radially and r = 0.75 (p ≤ 0.005) longitudinally. The soft plaque exhibited 35.1% (SD 16.9%) greater radial (p &lt; 0.001) and 88.6% (SD 72.0%) greater longitudinal (p &lt; 0.001) peak strain than the arterial wall when measured with speckle tracking. It was possible to estimate plaque strain by ST and to distinguish a soft plaque from the vessel wall via strain measurements.</p

Widman, Erik,

Caidahl, Kenneth,

Heyde, Brecht,

D’hooge, Jan,

Larsson, Matilda,

Swepub

Speckle tracking strain estimation of a carotid artery plaque phantom - Validation via sonomicrometry [Elektronisk resurs]

Digitala Vetenskapliga Arkivet - Academic Archive On-line

Publikationer från KTH

Widman, E

Caidahl, K

Heyde, B

D'hooge, J

Larsson, M

Speckle Tracking Strain Estimation of a Carotid Artery Plaque Phantom - Validation via Sonomicrometry

Erik Widman

Kenneth Caidahl

Brecht Heyde

Jan D'hooge

Matilda Larsson

Crossref

Duke Law Scholarship Repository