Between spring 1982 and autumn 1984 the physiological role of inositol 1,4,5-trisphosphate as a calcium-mobilising second messenger was first suggested and then experimentally established. At the same time the unexpected complexity of inositide metabolism began to be exposed by the discovery of inositol 1,3,4-trisphosphate. This article recalls my entanglement with these two inositol phosphates.This is the author accepted manuscript. The final version is available from Portland Press via http://dx.doi.org/10.1042/BST2015020

Irvine, Robin

Between spring 1982 and autumn 1984 the physiological role of Ins(1,4,5)P3 as a calcium-mobilizing second messenger was first suggested and then experimentally established. At the same time the unexpected complexity of inositide metabolism began to be exposed by the discovery of Ins(1,3,4)P3. This article recalls my entanglement with these two inositol phosphates

Apollo (Cambridge)

English

A tale of two inositol trisphosphates.

The use of peer-to-peer (P2P) applications is growing dramatically, particularly for sharing content such as video, audio, and software. The traffic generated by these applications represents a large proportion of Internet traffic. For the broadband access network providers P2P traffic presents several problems. This thesis identifies the performance and business issues that P2P traffic has on broadband access networks employing the McCircuit separation technique. A mechanism for managing P2P within the access network is proposed. The P2P diversion algorithm aims to manage P2P traffic within the access network based on layer 2 and layer 3 information without employing intrusive layer 7 traffic detection. To solve the contention problem experienced by best effort traffic in the access network, a solution based on the diversion algorithm and on a QoS based traffic classification scheme is proposed. A business model defining the business roles and pricing schemes is presented based on the features offered by the P2P diversion algorithm introducing new opportunities for gaining revenue from P2P traffic for the network service providers and providing better services to users.Användningen av peer-to-peer (P2P) applikationer ökar dramatiskt, speciellt för spridningen av video, musik, och mjukvara. Trafiken som skapas av dessa program utgör en stor del of trafiken på Internet. För bredbandsaccess operatörer ställer P2P trafik många problem. I detta examensarbete så identifieras både de egenskaper och affärsaspekter som P2P trafiken har på ett bredbandsaccessnät som använder McCircuit som seprationsmekanism för trafiken mellan användare och en mekanism, "peer-to-peer diversion mechansim" (P2PDA), för att hantera P2P trafiken i ett McCircuit baserat accessnät beskrivs. P2PDA algoritmen hanterar P2P trafik i accessnätet baserat på lager 2 och lager 3 information utan att ta hänsyn till applikationslagret (Lager 7). För att få en bra fördelning mellan best-effort trafik och prioriterad trafik så föreslås en lösning baserad på kombinationen av P2PDA och QoS baserad trafik klassificering. Slutligen så defineras en affärsmodell där affärsroller och olika varianter på prissättning för P2P diskuteras baserad på de egenskaper som den förslagna algoritmen medför och den ekonomiska vinst som denna lösning medger

A tale of two inositol trisphosphates

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