Póster presentado al 22nd IUBMB & 37th FEBS Congress: From Single Molecules to Systems Biology, celebrado en Sevilla (España) del 4 al 9 de septiembre de 2012DNA damage and repair are closely linked to cancer, not only
during tumor initiation and progression, but also as a potent antitumoral
therapeutical opportunity. From the many types of
damaged DNA, double strand breaks (DSBs) are specially relevant
in oncology. DSBs are repaired by two major mechanisms
that compete for the same substrate. Both ends of the DSB can
be simple re-joined with little or no processing, a mechanism
known as non-homologous end-joining. On the other hand,
DSBs can be processed and engaged in a more complex repair
pathway called homologous recombination. This pathway uses
the information present in a homologue sequence. The balance
between these two pathways is exquisitely controlled. Alterations
in the DSBs repair pathways facilitate tumor progression and are
selected early on during cancer development. On the other hand,
DSBs are the molecular base of radiotherapies and several
chemotherapies. Little is known about how cells chose between
these two repair pathways, or the relevance of such choice in cancer
initiation, progression or treatment. A main player for this
election is the protein known as CtIP, which has been loosely
implicated with cancer. We are studying the role of CtIP as a
tumor suppressor and its importance in tumor initiation, progression,
prognosis and treatment using cancer samples and cancer
cell models.Peer Reviewe