Spanish Ministerio de Ciencia e Innovación, MICINN [BFU2009-08137 to A.B.-H., EUI2008-00158 and BIO2010-20696 to C.B.]; Junta de Andalucía [CTS-5077 to A.B.-H.]; University of Granada-GREIB Project [GREIB.PYR_2010_12 to C.R.-L.]; Spanish Council for Scientific Research [201120E004 to A.B.-H.]; FEDER funds from the EU [to A.B.-H. and C.B.]; Instituto de Salud Carlos III [to CIBERehd]. Funding for open access charge: Spanish Ministerio de Ciencia e Innovación, MICINN [BFU2009-08137 to A.B.-H.].Peer reviewe