II Certamen Poeticum Linguae Latinae, celebrat al  Col.legi Universitari de Girona el 30 d'abril de 198

Condom i Gratacòs, Dolors

Medina, Jaume

Vilallonga, Mariàngela

Frontiers in Microbiology

PubMed

DUGiMedia – Universitat de Girona

II Certamen Poeticum Linguae Latinae

The microorganisms in the human gastrointestinal tract have a profound influence on the transformation of food into metabolites which can impact human health. Gallic acid and pyrogallol are bioactive compounds displaying diverse biological properties, including carcinogenic inhibiting activities. However its concentration in fruits and vegetables is generally low. These metabolites can be also generated as final products of tannin metabolism by microbes endowed with tannase, which opens up the possibility of their anti-cancer potential being increased. Patients with colorectal cancer display an imbalanced gut microbiota respect to healthy population. The recent use of next generation sequencing technologies has greatly improved knowledge of the identity of bacterial species that colonize non-tumorous and tumorous tissues of colorectal cancer patients. This information provides a unique opportunity to shed light on the role played by gut microorganisms in the different stages of this disease. We here review the recently published gut microbiome associated to colorectal cancer patients and highlight tannase as an underlying gene function of bacterial species that selectively colonize tumorous tissues, but not adjacent non-malignan

Félix eLópez De Felipe

Blanca ede las Rivas

Rosario eMuñoz

Directory of Open Access Journals

Bioactive compounds produced by gut microbial tannase: implications for colorectal cancer development

FÃ©lix LÃ³pez de Felipe

Blanca de las Rivas

Rosario MuÃ±oz

Frontiers - Publisher Connector

The microorganisms in the human gastrointestinal tract have a profound influence on the transformation of food into metabolites which can impact human health. Gallic acid (GA) and pyrogallol (PG) are bioactive compounds displaying diverse biological properties, including carcinogenic inhibiting activities. However, its concentration in fruits and vegetables is generally low. These metabolites can be also generated as final products of tannin metabolism by microbes endowed with tannase, which opens up the possibility of their anti-cancer potential being increased. Patients with colorectal cancer (CRC) display an imbalanced gut microbiota respect to healthy population. The recent use of next generation sequencing technologies has greatly improved knowledge of the identity of bacterial species that colonize non-tumorous and tumorous tissues of CRC patients. This information provides a unique opportunity to shed light on the role played by gut microorganisms in the different stages of this disease. We here review the recently published gut microbiome associated to CRC patients and highlight tannase as an underlying gene function of bacterial species that selectively colonize tumorous tissues, but not adjacent non-malignant tissues. Given the anti-carcinogenic roles of GA and PG produced by gut tannin-degrading bacteria, we provide an overview of the possible consequences of this intriguing coincidence for CRC development.This work was supported by grant AGL2011-22745.Peer Reviewe

López de Felipe, Félix

Rivas, Blanca de las

Muñoz, Rosario

Digital.CSIC

http://dx.doi.org/10.3389/fmicb.2014.00684

II Certamen Poeticum Linguae Latinae

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DUGiMedia – Universitat de Girona

Directory of Open Access Journals

Frontiers - Publisher Connector

Digital.CSIC