Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2005.Includes bibliographical references (leaves 86-88).Porous collagen-glycosaminoglycan (CG) scaffolds have been studied extensively and proven to be capable of tissue regeneration in vivo for applications including skin regeneration templates, hollow nerve guides and conjunctiva regeneration. While the current CG scaffold has been thoroughly examined both mechanically and clinically, it has yet to prove appropriate for load- bearing applications. This study will investigate the mechanical properties of a mineralized CG scaffold and its application potential in a load-bearing environment. Through the introduction of calcium-phosphate mineral into the standard CG formulation the matrix analog will be available for bone regeneration. Utilizing a patented triple co-precipitation technique developed at Massachusetts Institute of Technology and Cambridge University, a homogeneous mineralized scaffold will be manufactured. Comparison to healthy trabecular bone as well as the selection of the most appropriate extracellular matrix analog will be presented. The key to commercial success is the introduction of a bi-layer bone and cartilage regeneration template to address concerns and difficulties in cartilage repair today. This dual combination is termed a layered osteochondral scaffold.(cont.) The commercial viability of this product as well as the company founded on its inception, OrthoCaP, Inc., is delivered as a start-up venture over the next eight to ten years. With several key patents already filed, an extensive patent search was completed to establish leading competitors and technology in the marketplace. Although still in the primary phases of development, short-term profitability can be seen through licensing the technology to larger more secure firms. Long-term profitability is realized through a more scientific approach of broadening the technology to other areas of tissue regeneration and modifying the mechanical and material characteristics associated with collagen based templates.by Cassandra Holzgartner Ott.M.Eng
