CORE
🇺🇦
make metadata, not war
Services
Services overview
Explore all CORE services
Access to raw data
API
Dataset
FastSync
Content discovery
Recommender
Discovery
OAI identifiers
OAI Resolver
Managing content
Dashboard
Bespoke contracts
Consultancy services
Support us
Support us
Membership
Sponsorship
Community governance
Advisory Board
Board of supporters
Research network
About
About us
Our mission
Team
Blog
FAQs
Contact us
Time-course regulation of quercetin on cell survival/ proliferation pathways in human hepatoma cells
Authors
Laura Bravo
Luis Goya
+3 more
Ana B. Granado-Serrano
M. Angeles Martín
Sonia Ramos
Publication date
1 January 2008
Publisher
'Wiley'
Doi
Cite
Abstract
Quercetin, a dietary flavonoid, has been shown to possess anticarcinogenic properties, but the precise molecular mechanisms of action are not thoroughly elucidated. This study was aimed at investigating the time-course regulation effect of quercetin on survival/proliferation pathways in a human hepatoma cell line (HepG2). Quercetin induced a significant time-dependent inactivation of the major survival signaling proteins, i. e., phosphatidylinositol 3-kinase (PI 3-kinase)/protein kinase B (AKT), extracellular regulated kinase (ERK), protein kinase C-α (PKC-α), in concert with a time-dependent activation of key death-related signals: c-jun amino-terminal kinase (JNK) and PKC-δ. These data suggest that quercetin exerts a tight regulation of survival/proliferation pathways that requires the integration of different signals and persists over time, being the balance of these regulatory signals what determines the fate of HepG2 cells. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.This work was sup-ported by the grants AGL2004-302 from the Spanish Ministry of Science and Technology (CICYT), and 200570M050from the Comunidad de Madrid (CAM). A. B. G.–S. is a pre-doctoral fellow of the Spanish Ministry of Science and Edu-cation and S. R. has a Ramón y Cajal contract from theSpanish Ministry of Science and Technology.Peer reviewe
Similar works
Full text
Available Versions
Digital.CSIC
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:digital.csic.es:10261/8378...
Last time updated on 25/05/2016