We describe the application of conditional random fields (CRF) to physiological data modeling for the application of activity recognition. We use the data provided by the Physiological Data Modeling Contest (PDMC), a Workshop at ICML 2004. Data used in PDMC are sequential in nature: they consist of physiological sessions, and each session consists of minute-by-minute sensor readings. We show that linear chain CRF can effectively make use of the sequential information in the data, and, with Expectation Maximization, can be trained on partially unlabeled sessions to improve performance. We also formulate a mixture CRF to make use of the identities of the human subjects to further improve performance. We propose that mixture CRF can be used for transfer learning, where models can be trained on data from different domains. During testing, if the domain of the test data is known, it can be used to instantiate the mixture node, and when it is unknown (or when it is a completely new domain), the marginal probabilities of the labels over all training domains can still be used effectively for prediction.Singapore-MIT Alliance (SMA