CYFRA 21-1 as a tool for distant metastasis detection in lung cancer

Abstract

[Background] A study to analyse tumor markers (CEA, CA125, CA15.3, CA19.9, CYFRA 21-1, and NSE) for metastasis detection in lung cancer patients.[Methods] Serum tumor markers from 73 lung cancer patients were measured before they were diagnosed. After lung cancer diagnosis, tumor markers were analyzed for the detection of distant metastases.[Results] In NSCLC patients CYFRA 21-1 and NSE showed differences between stage IV and any of the other stages, p <0.05. The accuracy for metastasis detection was AUC = 81.5% for CYFRA 21-1 and AUC = 78.6% for NSE. CYFRA 21-1 (OR = 1.406; 95% CI, 1.087 - 1.821, p <0.01) and NSE (OR = 1.197; 95% CI, 1.011 - 1.416, p <0.05) were independent predictors for metastasis presence. No tumor marker showed significant differences according to stages in SCLC patients.[Conclusions] CYFRA 21-1 could be used as a screening tool for metastasis detection in lung cancer patients without symptoms of metastasis as well as CYFRA 21-1 and NSE in NSCLC patients.Peer Reviewe