3 pages, 1 figure, 7 references.-- Congreso celebrado del 7-10 septiembre 1987 en Sevilla, España.-- EUROCLAY'87.Clay-drug interactions have been widely studied during the last decade.
However, the reaction mechanisms responsible of these interactions
only have been elucidated in sorne cases (1,2), most of them when cationic
drugs are ínvolved. Neutral molecules are known to interact with
clays by physical adsorption (3), and/or by hydrogen bonding (4). Dioxin
is adsorbed onto montmorillonite by a reversible adsorption mechanism
(5) and degrades by acid-catalyzed hydrolisis. The mechanism of ad
sorption and degradation of the neutral steroid hydrocortisone by palygorskite
and sepio1ite has be en recently studied (6,7). Two types of ferric iron present in these clays may be responsible for the different
degradation rates of hydrocortisone.Peer reviewe
