Uncatalyzed Three-Component Synthesis of α-Hydrazido Phosphonates

Abstract

5 páginas, 2 figuras, 3 tablas, 2 esquemas.Various α-hydrazido phosphonates have been easily prepared on the basis of the nucleophilic addition of diphenyl phosphite to reactive, preformed N-acylhydrazones and a three-component (aldehydes, N-benzoylhydrazide and diphenyl phosphite) coupling reaction through a non-catalyzed process. An unprecedented and promising enantioselective example of this reaction is also reported.We thank the High Council of Scientific Investigation (CSIC) (PIE-200880I260), the Ministry of Science and Innovation (MICINN, Madrid, Spain) (Project CTQ2009-09028) and the Government of Aragón (Zaragoza, Spain) (Project PI064/09) for financial support of our research.Peer reviewe