2 pages.-- PMID: 20814544 [PubMed].-- PMCID: PMC2931383].Peer reviewe

Daniela Montesarchio

Jean-Louis Mergny

Lea Spindler

Mateus Webba da Silva

Ramon Eritja

Journal of Nucleic Acids

English

PubMed

Eritja Casadellà, Ramón

Mergny, Jean-Louis

Montesarchio, Daniela

Spindler, Lea

Webba Da Silva, Mateus

Digital.CSIC

G-quadruplex nucleic acids

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G-Quadruplex Nucleic Acids

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SAGE-Hindawi Access to ResearchJournal of Nucleic AcidsVolume 2010, Article ID 147650, 2 pagesdoi:10.4061/2010/147650EditorialG-Quadruplex Nucleic AcidsRamon Eritja,1 Jean-Louis Mergny,2 Daniela Montesarchio,3 Lea Spindler,4, 5and Mateus Webba da Silva61 IRB Barcelona, IQAC-CSIC, Jordi Girona 16-26, 08034 Barcelona, Spain2 2 INSERM U869, Laboratoire ARNA, Universite´ de Bordeaux 2, Institut Europe´en de Chimie-Biologie, 2 rue Robert Escarpit,33607 Pessac Cedex, France3Dipartimento di Chimica Organica e Biochimica, Universita` degli Studi di Napoli “Federico II”, I-80126 Naples, Italy4 Faculty of Mechanical Engineering, University of Maribor, Smetanova 17, SI-2000 Maribor, Ljubljana, Slovenia5Department of Complex Matter, J. Stefan Institute, Jamova 39, SI-1000, Ljubljana, Slovenia6Faculty of Life and Health Sciences, University of Ulster, Cromore Road, Coleraine, BT52 1SA, Northern IrelandCorrespondence should be addressed to Ramon Eritja, recgma@cid.csic.esReceived 9 June 2010; Accepted 9 June 2010Copyright © 2010 Ramon Eritja et al. This is an open access article distributed under the Creative Commons Attribution License,which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.G-quadruplexes are a family of four-stranded structuresstabilized by guanine quartets, in which four planar guaninesestablish a cyclic array of hydrogen bonds. They are ofspecial interest due to the increasing evidence for theirformation in vivo and their possible implication in biology,especially at telomeres and as contributors to gene regulation.Moreover, G-quadruplexes are also formed as a result ofself-assembling processes of guanosine derivatives, yieldingseveral interesting motifs such as G-ribbons and G-wireswhich have peculiar electrical conductivity properties thatare being explored as molecular wires.This special issue is initiated with two articles discussingthe self-assembling properties of guanosine derivatives whichdescribe the basic principles of G-quadruplex formation. Thefirst article by Neviani et al. analyzes the presence of severallevels of organization of guanosine derivatives carryingone or two lipophilic units as observed by light scatteringtechniques and transmission electron microscopy (TEM)experiments. The second article by Mariani et al. describesa study on quadruplex formation of 2′-deoxyguanosinemonophosphate by small-angle X-ray scattering techniques.The determination of the structural properties of shortG-rich oligonucleotides is the aim of the following threearticles. First the formation and dimensions of G-wiresformed by the assembly of short G-rich sequences have beeninvestigated by dynamic light scattering and electrophoresis.Spindler et al. show that macromolecular aggregates formedby self-assembly of quadruplex (G-wires) up to 11 nm canbe observed. Next, the structure of a G-quadruplex formedbetween two cyclic oligonucleotides determined by nuclearmagnetic resonance (NMR) and circular dichroism (CD)is described by Casals et al. Due to steric constraints, theglobal topology and the stability of the antiparallel G-quadruplex are diﬀerent from the linear oligonucleotides.The adsorption and the redox behaviour of two intramolec-ular G-quadruplexes related with the thrombin bindingaptamer are studied by atomic force microscopy (AFM)and voltammetry. Quadruplexes have distinct adsorptionproperties and redox behaviour that are characterized byDiculescu et al. in this article.The natural occurrence and properties of G-quadruplexsequences including telomeres are the aim of the nextthree articles. Wong et al. provide useful information on acomputational tool currently available at http://www.qua-druplex.org/ for predicting the formation of G-quadruplexfrom sequence data. Next, a comparative study of the impactof G-spot probes on aﬀymetrix GeneChips of mammalia isdescribed by Memon et al. The thermodynamic propertiesof human telomeric repeats are the aim of the next articleby Viglaski et al. demonstrating the importance of theoverhanging sequences as a determining factor for thethermal stability and topology of G-quadruplexes.The last section of this special issue is devoted to thestudy of the binding of small molecules to G-quadruplexes.An extensive up-to-date review on macrocyclic ligands forG-quadruplex DNA recognition by Monchaud et al. isheading this section. A second manuscript by Granzhan et al.describes the search of cyclophan-type macrocycles with2 Journal of Nucleic Acidsenhanced selective binding to quadruplex over duplex DNAsequences. The characterization of the binding of distamycinA derivatives to the tetrameric parallel TGGGGT quadruplexby isothermal titration calorimetry (ITC) is the aim of thework of Pagano et al. In a successive study, the binding modeof telomestatin to G-quadruplex DNA has been analyzed bymass spectrometry. The requirement of an extra monovalentcation between telomestatin and G-quadruplex DNA isanalyzed by molecular modelling by Gabelica et al. Thesynthesis and properties of novel ligands for G-quadruplexstructures are addressed in the next two articles. Iida et al.describe the synthesis of a dimeric macrocyclic hexaoxazolewith enhanced aﬃnity to telomeric DNA. Ferreira et al.describe the synthesis of dimeric and trimeric acridineswith aﬃnity to G-quadruplex structures found in promoterregions of oncogenes. Finally the interactions of porphyrin-Zinc (II) complexes with an intramolecular G-quadruplexhave been analyzed by spectroscopic and docking methodsby Ishikawa et al.The editors of the issue would like to thank all the authorsand referees involved in the production and evaluationof the manuscripts for their eﬀorts in the preparation ofthis first special issue of the Journal of Nucleic Acids.This special issue shows the large interdisciplinarity andinternational scope of the research on G-quadruplex. Specialthanks are given to the COST Action MP0802 entitled “Self-assembled guanosine structures for molecular electronicdevices” (G4net, http://www.g4net.org/) for providing the“natural” forum of discussion and elaboration of ideas, aswell as an excellent technical assistance, absolutely preciousfor the development of this special issue.Ramon EritjaJean-Louis MergnyDaniela MontesarchioLea SpindlerMateus Webba da SilvaSubmit your manuscripts athttp://www.hindawi.comHindawi Publishing Corporationhttp://www.hindawi.com Volume 2014 Anatomy Research InternationalPeptidesInternational Journal ofHindawi Publishing Corporationhttp://www.hindawi.com Volume 2014Hindawi Publishing Corporation http://www.hindawi.com International Journal ofVolume 2014ZoologyHindawi Publishing Corporationhttp://www.hindawi.com Volume 2014Molecular Biology International GenomicsInternational Journal ofHindawi Publishing Corporationhttp://www.hindawi.com Volume 2014The Scientific World JournalHindawi Publishing Corporation http://www.hindawi.com Volume 2014Hindawi Publishing Corporationhttp://www.hindawi.com Volume 2014BioinformaticsAdvances inMarine BiologyJournal ofHindawi Publishing Corporationhttp://www.hindawi.com Volume 2014Hindawi Publishing Corporationhttp://www.hindawi.com Volume 2014Signal TransductionJournal ofHindawi Publishing Corporationhttp://www.hindawi.com Volume 2014BioMed Research InternationalEvolutionary BiologyInternational Journal ofHindawi Publishing Corporationhttp://www.hindawi.com Volume 2014Hindawi Publishing Corporationhttp://www.hindawi.com Volume 2014Biochemistry Research InternationalArchaeaHindawi Publishing Corporationhttp://www.hindawi.com Volume 2014Hindawi Publishing Corporationhttp://www.hindawi.com Volume 2014Genetics Research InternationalHindawi Publishing Corporationhttp://www.hindawi.com Volume 2014Advances inVirolog yHindawi Publishing Corporationhttp://www.hindawi.comNucleic AcidsJournal ofVolume 2014Stem CellsInternationalHindawi Publishing Corporationhttp://www.hindawi.com Volume 2014Hindawi Publishing Corporationhttp://www.hindawi.com Volume 2014Enzyme ResearchHindawi Publishing Corporationhttp://www.hindawi.com Volume 2014International Journal ofMicrobiology

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