单个α-粒子的细胞效应

Abstract

为研究生物学上的单粒子效应 ,阐明空间带电粒子生物效应的机理 ,采用一台小型α-放射源微束装置和CN核径迹探测器 ,以双倍体酵母菌作为真核细胞试验体系 ,通过电荷耦合摄像系统 ,得到细胞失活与α-粒子 -细胞碰撞参数之间的关系。结果表明 ,1 .1 3MeV/uα -粒子在细胞 -琼脂混合物中失活范围可达 5.5μm ,大于离子径迹晕半径与酵母细胞半径之和 (约 3 .1 μm)。细胞失活率在 0 .3 6～ 0 .3 3之间。提示 :细胞要由失活到致死 ,需要多次击中 ,然而在未击中情况下 ,失活几率在一定碰撞参数下未必为零。The mechanisms of biological effect of charged particles in space was studied through the inactivation effect of very low-density charged particles on very low-density cells at different impact parameters. A small type of microbeam facility with α-radioactive source and CN track detector were used.A diploid wild type Saccharomyces cerevisiae served as experimental eukaryotic cell.The correlation between cell inactivation and impact parameter of α-particles on cells was obtained through a CCD-camera system.T...王宽诚教育基金会资