Small interfering RNA (siRNA) based therapeutics for cancer treatments have gained considerable attention due to the high potency of siRNA in suppressing pathogenic gene
expression [1]. Yet, there are drawbacks that limit siRNA application in vivo: the vulnerability of siRNA against nucleases and the inability of the nucleic acids molecules
to diffuse across the cellular membranes. Nanovectors hold great promise for overcoming these limitations towards the development of efficient siRNA therapy.
Various nanovectors such as lipids, polymers and inorganic nano-particles have been extensively studied. Among these nanovectors, mesoporous silica nanoparticles (MSN) show promising potential as the next-generation gene delivery carriers
