Effects on the Acquisition of DRL-20 Performance of Propranolol or Isoproterenol Injected into the Basolateral Amygdala of Rats

Abstract

The acquisition of DRL-20 performance by rats is significantly disrupted by 20 μg of propranolol and significantly improved by 37 μg of isoproterenol injected into the basolateral amygdala prior to each daily testing session. Autoradiography of [14C]propranolol injected into the basolateral amygdala indicates that the injected propranolol remains within 1 mm of the injection site. This suggests that the β-adrenergic receptors in the basolateral amygdala are somehow involved in the elimination of maladaptive behavior. </jats:p