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research
Single shot three-dimensional pulse sequence for hyperpolarized 13 C MRI.
Authors
Ardenkjaer
Asslander
+38 more
Beatty
Bedard
Brindle
Brindle
Brindle
Brindle
Cunningham
Cunningham
Cunningham
Day
Durst
Glover
Gorp
Hu
Hu
Irarrazabal
Irarrazabal
Josan
Junttila
Kettunen
Lai
Larson
Larson
Larson
Lau
Levin
Mayer
Mayer
Miller
Nelson
Pauly
Pauly
Qin
Schulte
Shu
Wiesinger
Wu
Xu
Publication date
24 February 2016
Publisher
Magn Reson Med
Doi
Cite
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on
PubMed
Abstract
PURPOSE: Metabolic imaging with hyperpolarized 13 C-labeled cell substrates is a promising technique for imaging tissue metabolism in vivo. However, the transient nature of the hyperpolarization, and its depletion following excitation, limits the imaging time and the number of excitation pulses that can be used. We describe here a single-shot three-dimensional (3D) imaging sequence and demonstrate its capability to generate 13 C MR images in tumor-bearing mice injected with hyperpolarized [1-13 C]pyruvate. METHODS: The pulse sequence acquires a stack-of-spirals at two spin echoes after a single excitation pulse and encodes the kz-dimension in an interleaved manner to enhance robustness to B0 inhomogeneity. Spectral-spatial pulses are used to acquire dynamic 3D images from selected hyperpolarized 13 C-labeled metabolites. RESULTS: A nominal spatial/temporal resolution of 1.25 × 1.25 × 2.5 mm3 × 2 s was achieved in tumor images of hyperpolarized [1-13 C]pyruvate and [1-13 C]lactate acquired in vivo. Higher resolution in the z-direction, with a different k-space trajectory, was demonstrated in measurements on a thermally polarized [1-13 C]lactate phantom. CONCLUSION: The pulse sequence is capable of imaging hyperpolarized 13 C-labeled substrates at relatively high spatial and temporal resolutions and is robust to moderate system imperfections. Magn Reson Med 77:740-752, 2017. © 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.The work was supported by a Cancer Research UK Programme grant (17242) to KMB and by the CRUK-EPSRC Imaging Centre in Cambridge and Manchester (16465). JW was also supported, in part, by a grant from the Danish Strategic Research Council (LIFE-DNP: Hyperpolarized magnetic resonance for in vivo quantification of lipid, sugar and amino acid metabolism in lifestyle related diseases).This is the final version of the article. It first appeared from Wiley via https://doi.org/10.1002/mrm.2616
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info:doi/10.1002%2Fmrm.26168
Last time updated on 27/03/2019
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Apollo (Cambridge)
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Last time updated on 18/05/2016