The application of an ecosystem approach to management of the sea requires both integrated and strategic frameworks such as Integrated Coastal Zone Management (ICZM) and the use of marine spatial planning (MSP) to minimize spatial use conflicts and environmental degradation. Such an integrated management promotes sustainable development based on achieving a balance of environmental, social and economic objectives. Here we introduce a first draft of a generic framework which is developed in the EU FP7 project MESMA that gives guidance on how to assess the effectiveness of an existing management within a spatially defined area. More precisely, we define spatially managed areas as geographical entities where a marine planning framework is or will be used to manage multiple human activities in space and time while aiming to maintain ecosystem integrity. The framework consists of seven steps and comprises practical guidance on the selection of operational objectives and related criteria (step 1), the collation and integration of information (steps 2, 3 and 4), performance assessment (step 5), and feedback processes (steps 6 and 7). In the course of the MESMA project, this generic framework will be applied and tested in nine case studies, representing all European seas. Here we highlight the processes and practical tasks involved in each of the framework steps, reflect on the first attempts to implement this framework and identify the requirements for practical tools such as standardized methods to map human activities and assess their cumulative impacts