Development and Evaluation of Novel Biodegradable Docetaxel Loaded Microspheres of Poly (D, L-Lactide-Co-Glycolic acid) and Poly (ε-Caprolactone)for Controlled Drug Delivery.

Abstract

The main objective of this study was to develop a polymeric drug delivery system for controlled release of docetaxel. This system was capable of improving the therapeutic index of drug and devoid of adverse effect of polysorbate 80 in Taxotere. Polycapro-ε lactone (PCL) and poly (lactic –coglycolic acid) (PLGA) microspheres were prepared by solvent evaporation method. Solvent evaporation method was used for the successful entrapment of drug with in polymer particles. The influence of different processing parameters on the size and surface morphology of microspheres was evaluated. Effect of docetaxel concentration on encapsulation efficiency and released pattern was also studied. We achieved good encapsulation efficiency i.e 92.19 ± 0.23, 86.38 ± 0.02 for F1 ( 1:2 Drug: PCL) and F4 ( 1:2 drug : PLGA) formulations respectively. Cumulative % drug released was found 56.95± 0.024 for PCL (F1) and 80.54± 0.035 for PLGA (F4) formulation after 30 days incubation in PBS buffer (pH 7.4). Both the formulation followed higuchi model and the release mechanism was found non fickian on the basis of diffusion exponent value of 0.86 and 0.83 for F1 and F4 formulation respectively. The formulations were found stable and very effective for controlled drug delivery