The European NEAT program: an integrated approach using acamprosate and psychosocial support for the prevention of relapse in alcohol-dependent patients with a statistical modeling of therapy success prediction.

Abstract

Multicenter, prospective study in five European countries to observe outcome in alcohol misusers treated for 24 weeks with acamprosate and various psychosocial support techniques, within the setting of standard patient care. 1289 patients were recruited,543 (42.1%)patients were observed for the full 24-week period. The overall proportion of cumulative abstinence days was 0.48. Multiple physical and psychiatric comorbidities and a history of drug addiction were negatively correlated with outcome, as were, to a lesser extent, multiple previous episodes of detoxification, unemployment, and living alone. Older age and stable employment were positively associated with outcome. The difference in the unadjusted proportion of cumulative abstinence days between countries was significant (p< 0.001). Overall, outcome was not influenced by the nature of the psychosocial support provided. Adverse events were generally mild, with gastrointestinal disorders, which occurred in 21.5% of patients.Multicentre, prospective study dans 5 pays Europeens pour observation de patients alcooliques traités sur 24 semaines avec acamprosate et des psychotherapies variées. 1289 patients ont été recrutés,543 (42.1%)patients ont terminés normalement au bout des 24 semaines. La proportion de cumulative abstinence days CAD fut de 0.48. La difference dans la proportion de CAD ajustée fut significative entre les pays(p< 0.001). Il semble que le devenir ne soit pas dépendant du choix de la psychothérapie