The American Society for Biochemistry and Molecular Biology, Inc.
Abstract
ABSTRACTBackground: PPAR agonists improve insulin sensitivity but also evoke weight gain.
Results: GQ-16 is a PPAR partial agonist that blocks receptor phosphorylation by Cdk5 and improves insulin sensitivity in diabetic mice in the absence of weight gain. Conclusion: The unique binding mode of GQ-16 appears to be responsible for the compound’s advantageous pharmacological profile.
Significance: Similar compounds could have promise as anti-diabetic therapeutics
