In recent years, calcium hydroxyapatite (HAp) and its substituents are increasingly used in dentistry and medicine. The influence of nanoparticles Ca / Co-HAp in strengthening weak osteoporotic bone jaw tegmenta was tested in an experimental model. The study was conducted on Wistar soy rats, aged 6-8 weeks. The biomaterial was implanted in the osteoporoticly weakened mandible of these animals. The best results in the strengthening of the lower jaw bone tegmenta were achieved 24 weeks after implantation of hydroxyapatite nanoparticles in which the calcium ion was substituted with 12% of cobalt ions. Histochemical parameters of bone synthesis were in a statistically significant increase. SEM analysis showed a high degree of osteogenetic ability of nano-particulate material implanted in the bone defect

Ajduković, Zorica

Ignjatović, Nenad

Mihailović, D.

Najman, Stevo

Petrović, N.

Rajković, J.

Savić, Vojin

Uskoković, Dragan

Digital Repository of the Institute of Technical Sciences of SASA

FOURTEENTH ANNUAL CONFERENCE  
 
YUCOMAT 2012 
Hunguest Hotel Sun Resort Herceg Novi, Montenegro,  
September 3–7, 2012 
http://www.mrs-serbia.org.rs 
 
 
 
 
Programme  
and  
The Book of Abstracts 
 
 
 
Organised by: 
Materials Research Society of Serbia 
 
 
under the auspices of 
Federation of European Material Societies 
and 
Materials Research Society 
Title:  THE FOURTEENTH ANNUAL CONFERENCE 
YUCOMAT 2012 
Programme and the Book of Abstracts 
 
 
 
Publisher: Materials Research Society of Serbia 
  Knez Mihailova 35/IV, 11000 Belgrade, Serbia 
  Phone: +381 11 2185-437; Fax: + 381 11 2185-263 
  http://www.mrs-serbia.org.rs 
 
 
 
 
Editor:  Prof. Dr. Dragan P. Uskoković 
 
Technical editor:  Aleksandra Stojičić 
 
Cover page:  Aleksandra Stojičić and Milica Ševkušić 
 
 
 
 
Copyright © 2012 Materials Research Society of Serbia 
 
 
Acknowledgment:  
                  
 
         
 
 
Printed in: Biro Konto 
  Sutorina bb, Igalo – Herceg Novi, Montenegro  
  Phones: +382-31-670123, 670025, E-mail: bkonto@t-com.me 
  Circulation: 200 copies. The end of printing: August 2012 
FOURTEENTH ANNUAL CONFERENCE 
YUCOMAT 2012 
Herceg Novi, September 3-7, 2012 
 121
P.S.E.17. 
REGENERATION BONE TISSUE BY NEW NANOPARTICULES SYSTEM BASED  
ON HYDROXIAPATITE AS SYSTEMS FOR LOCAL DELIVERY OF VITAMIN D3 
 
Z. Ajduković1, M. Petrović1, N. Ignjatović2, V. Savić3, D. Mihailović4, D. Uskoković2 
1Faculty of Medicine, Clinic of Stomatology, Department of Prosthodontics, Niš, Serbia, 2Institute 
of Technical Sciences of SASA, Belgrade, Serbia, 3Faculty of Medicine, Niš, Institute of 
Biomedical Research, Serbia, 4Faculty of Medicine, Niš, Institute of Pathology, Serbia 
 
Increased life expectancy in developed countries leads to an increase in the number of 
musculoskeletal disordes, such as osteoporosis, oasteoratritis thus compromising good dental 
treatment.  There are many drug delivery systems based on hydroxiapatite used in bone tissue 
regeneration. Vitamin D3 is osteodiferentiation factor which regulates bone formation by 
increasing osteoblast differentiation and bone mineralization. The aim of this study is to examine 
new multifunctional nanoparticulate system for local delivery of active form of vitamin D3 by 
biochemical blood marker and histochemical analysis. The research was carried out on female 
Westar rats, aged 6-8 weeks, which have been implanted biomaterials in the artificial bone defect. 
Biochemical markers of osteogenesis were statistically significant after only 6 weeks of 
implantation. ALP activity in bone tissue was showed by histochemical analysis as well as high 
level reparatory skills. Local realized Vitamin D3 contribute to bone formation by increasing 
osteoblast differentiation and bone mineralization 
Key words: nanoparticles drug delivery system, vitamin D3, alveolar bone, regeneration. 
 
 
P.S.E.18. 
HYDROXYAPATITE AND HYDROXYAPATITE SUBSTITUENTS IN 
STRENGTHENING OF THE JAW BONE TEGMENTA 
 
Z. Ajduković1, N. Ignjatović2, V. Savić3, S. Najman3,  
D. Mihailović4, J. Rajković5, N. Petrović1, D. Uskoković2 
1University of Niš, Faculty of Medicine, Clinic of Stomatology, Department of Prosthodontics, 
Serbia, 2Institute of Technical Sciences of SASA, Belgrade, Serbia, 3University of Niš, Faculty of 
Medicine, Institute of Biomedical Research, Serbia, 4University of Niš, Faculty of Medicine, 
Institute of Pathology, Serbia, 5University of Niš, Department of Biology and Ecology, Faculty of 
Science, Serbia 
 
In recent years, calcium hydroxyapatite (HAp) and its substituents are increasingly used in 
dentistry and medicine. The influence of nanoparticles Ca / Co-HAp in strengthening weak 
osteoporotic bone jaw tegmenta was tested in an experimental model. The study was conducted 
on Wistar soy rats, aged 6-8 weeks. The biomaterial was implanted in the osteoporoticly weakend 
mandible of these animals. The best results in the strengthening of the lower jaw bone tegmenta 
were achieved 24 weeks after implantation of hydroxyapatite nanoparticles in which the calcium 
ion was substituted with 12% of cobalt ions. Histochemical parameters of bone syntesis were in a 
statistically significant increase. SEM analysis showed a high degree of osteogenetic ability of 
nano particulate material implanted in the bone defect. 
Keywords: hydroxyapatite, Ca / Co-HAp, osteoporosis, jaw bone, osteogenesis. 


Hydroxyapatite and hydroxyapatite substituents in strengthening of the jaw bone tegmenta

Mihailović, Dragan

Serbian Academy of Science and Arts Digital Archive (DAIS)

FOURTEENTH ANNUAL CONFERENCE   YUCOMAT 2012 Hunguest Hotel Sun Resort Herceg Novi, Montenegro,  September 3–7, 2012 http://www.mrs-serbia.org.rs     Programme  and  The Book of Abstracts    Organised by: Materials Research Society of Serbia   under the auspices of Federation of European Material Societies and Materials Research Society Title:  THE FOURTEENTH ANNUAL CONFERENCE YUCOMAT 2012 Programme and the Book of Abstracts    Publisher: Materials Research Society of Serbia   Knez Mihailova 35/IV, 11000 Belgrade, Serbia   Phone: +381 11 2185-437; Fax: + 381 11 2185-263   http://www.mrs-serbia.org.rs     Editor:  Prof. Dr. Dragan P. Uskoković  Technical editor:  Aleksandra Stojičić  Cover page:  Aleksandra Stojičić and Milica Ševkušić     Copyright © 2012 Materials Research Society of Serbia   Acknowledgment:                                Printed in: Biro Konto   Sutorina bb, Igalo – Herceg Novi, Montenegro    Phones: +382-31-670123, 670025, E-mail: bkonto@t-com.me   Circulation: 200 copies. The end of printing: August 2012 FOURTEENTH ANNUAL CONFERENCE YUCOMAT 2012 Herceg Novi, September 3-7, 2012  121P.S.E.17. REGENERATION BONE TISSUE BY NEW NANOPARTICULES SYSTEM BASED  ON HYDROXIAPATITE AS SYSTEMS FOR LOCAL DELIVERY OF VITAMIN D3  Z. Ajduković1, M. Petrović1, N. Ignjatović2, V. Savić3, D. Mihailović4, D. Uskoković2 1Faculty of Medicine, Clinic of Stomatology, Department of Prosthodontics, Niš, Serbia, 2Institute of Technical Sciences of SASA, Belgrade, Serbia, 3Faculty of Medicine, Niš, Institute of Biomedical Research, Serbia, 4Faculty of Medicine, Niš, Institute of Pathology, Serbia  Increased life expectancy in developed countries leads to an increase in the number of musculoskeletal disordes, such as osteoporosis, oasteoratritis thus compromising good dental treatment.  There are many drug delivery systems based on hydroxiapatite used in bone tissue regeneration. Vitamin D3 is osteodiferentiation factor which regulates bone formation by increasing osteoblast differentiation and bone mineralization. The aim of this study is to examine new multifunctional nanoparticulate system for local delivery of active form of vitamin D3 by biochemical blood marker and histochemical analysis. The research was carried out on female Westar rats, aged 6-8 weeks, which have been implanted biomaterials in the artificial bone defect. Biochemical markers of osteogenesis were statistically significant after only 6 weeks of implantation. ALP activity in bone tissue was showed by histochemical analysis as well as high level reparatory skills. Local realized Vitamin D3 contribute to bone formation by increasing osteoblast differentiation and bone mineralization Key words: nanoparticles drug delivery system, vitamin D3, alveolar bone, regeneration.   P.S.E.18. HYDROXYAPATITE AND HYDROXYAPATITE SUBSTITUENTS IN STRENGTHENING OF THE JAW BONE TEGMENTA  Z. Ajduković1, N. Ignjatović2, V. Savić3, S. Najman3,  D. Mihailović4, J. Rajković5, N. Petrović1, D. Uskoković2 1University of Niš, Faculty of Medicine, Clinic of Stomatology, Department of Prosthodontics, Serbia, 2Institute of Technical Sciences of SASA, Belgrade, Serbia, 3University of Niš, Faculty of Medicine, Institute of Biomedical Research, Serbia, 4University of Niš, Faculty of Medicine, Institute of Pathology, Serbia, 5University of Niš, Department of Biology and Ecology, Faculty of Science, Serbia  In recent years, calcium hydroxyapatite (HAp) and its substituents are increasingly used in dentistry and medicine. The influence of nanoparticles Ca / Co-HAp in strengthening weak osteoporotic bone jaw tegmenta was tested in an experimental model. The study was conducted on Wistar soy rats, aged 6-8 weeks. The biomaterial was implanted in the osteoporoticly weakend mandible of these animals. The best results in the strengthening of the lower jaw bone tegmenta were achieved 24 weeks after implantation of hydroxyapatite nanoparticles in which the calcium ion was substituted with 12% of cobalt ions. Histochemical parameters of bone syntesis were in a statistically significant increase. SEM analysis showed a high degree of osteogenetic ability of nano particulate material implanted in the bone defect. Keywords: hydroxyapatite, Ca / Co-HAp, osteoporosis, jaw bone, osteogenesis. 

Hydroxyapatite and hydroxyapatite substituents in strengthening of the jaw bone tegmenta

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