Neuroleptici, donji jednjačni i pilorički sfinkter, sustav dušik oksida i pentadekapeptid BPC 157

Abstract

It is not known how dopamine antagonists, L-NAME, L-arginine and stable gastric pentadecapeptide BPC-157 would interact with lower esophageal and pyloric sphincter pressure in rats (LES, PS). We revealed a fall in pressure within LES and PS as an indicative class effect of peripherally and centrally acting antipsihotics. In addition, given intraperitoneally alone and/or combined, all agents once daily through seven days, last application 24h before pressure assessment, BPC-157 mostly dose-dependently, counteracts all pressure falls induced by all antipsihotics; L-NAME induced a marked fall in both sphincters and worsened haloperidol and domperidone-failure; Larginine induced a smaller fall in both sphincters, but reversed L-NAME effect, and partly counteracted dopamine antagonists failure effect (haloperidol (LES)) as well as worsening of both haloperidol (LES) and domperidone (PS)- failure induced by L-NAME. Additional counteracting effect of BPC-157 was general, including all pressure decrease otherwise induced by L-NAME or Larginine, as well as complete counteraction of both spihnicters pressure worsening of haloperidol and domperidone (PS)-failure otherwise induced by L-NAME administration. In conclusion, counteracting potential of BPC-157 (as well as counteracting potential of L-arginine) can be against the conditions of dopamine receptor blockade and NOS-blockade