Institute for Medical Research and Occupational Health
Abstract
Prikazan je tijek bolesti 63-godišnje bolesnice koja je u suicidalnoj namjeri uzela per os oko 10 mg medigoksina. Imala je znakove intoksikacije digitalisom: mučninu i povraćanje, u elektrokardiogramu atrioventrikularnu disocijaciju s fibrilacijom atrija·i koncenrraciju digoksina u plazmi od 19,9 nmol/L. Imala je znakove akutnog zatajenja bubrega i, u povezanosti s renalnom insuficijencijom, poluživot digoksina u plazmi iznosio je od 30 do 90 sati. EKG promjene korigiranog 0-T-intervala i P-T-Q-indeksa bile su u korelaciji s ostalim znakovima intoksikacije digitalisom. Sedmog dana bolesti koncentracija digoksina u plazmi iznosila je 2,5 nmol/L.The paper describes the course of ilness in a 63-year-old woman who ingested 10 mg of medigoxin with suicidal intent. The first signs of poisoning were nausea and vomiting. The electrocardiogram showed sings of atrioventricular dissociation and atrial fibrillation, and serum digoxin concentration was 19.9 nmol/L, The partien1: also had sings of acute renal failure with a renal failure index of 3.9. Digoxin half-life was between 30 and 90 hours, depending on renal damage. ECG signs of digitalis intoxication were in correlation with the corrected 0-T-interva! and P-T-0 index. On the seventh day of the ilness the serum digoxin concentration was 2.5 nmol/L
