Institute for Medical Research and Occupational Health
Abstract
Treatment with diazinon (40 mg/kg, i. p.) resulted in depletion of glycogen and increased activities of glycogen phosphorylase, phosphoglucomutase, hexokinase and lactate dehydrogenase in the brain of rats. The activity of glucose-o-phosphatase was not significantly changed. The level of lactic acid in the blood was raised, while that of pyruvic was not altered. The induced changes may be due to a compensatory mechanism providing extra energy on account of stimulatory effects in diazinon treated animals.Davanje diazinona (40 mg/kg i. p.) imalo je za posljedicu iscrpljenje glikogena u mozgu štakora te povećanu aktivnost glikogen fosforilaze, fosfoglukomutaze, heksokinaze i laktat dehidrogenaze. Aktivnost glukoza-6-fosfataze nije bila značajnije promijenjena. Razina mliječne kiseline u krvi bila je povećana, dok se koncentracija pirogrožđane kiseline nije mijenjala. Ove inducirane promjene mogu biti posljedica kompenzacijskog mehanizma da bi se stvorila dodatna energija kao posljedica stimulatornih učinaka diazinona u trovanih životinja
