Institute for Medical Research and Occupational Health
Abstract
The effect of diazinon, given intraperitoneally, on the distribution of pp\u27DDT was determined in certain brain regions of rats. pp\u27DDT concentration expressed per gram of wet weight was highest in the corpus striatum (2575 ng/g) followed by those in the cerebellum (1850 ng/g) and in the cortex (990 ng/g). Pretreatment with diazinon increased pp\u27DDT accumulation in various brain regions by about 20 per cent (corpus striatum 2995 ng/g; cerebellum 2240 ng/g and cortex 1245 ng/g) and reduced cholinesterase activity by 50 - 70 per cent.Određivan je učinak intraperitonealno davanog diazinona na raspodjelu pp\u27DDT u nekim dijelovima mozga u štakora. Koncentracija pp\u27DDT po gramu težine mozga bila je najviša u korpusu strijatumu (2575 ng/g), zatim malom mozgu (1850 ng/g) i kori velikog mozga (990 ng/g). Prethodni tretman diazinonom povećao je akumulaciju pp\u27DDT u regijama mozga štakora za oko 20% (korpus strijatum 2995 ng/g, mali mozak 2240 ng/g, kora velikog mozga 1245 ng/g). Aktivnost acetilkolinesteraze mozga smanjila se za 50 do 70%
