Institute for Medical Research and Occupational Health
Abstract
Human T cells, isolated from peripheral blood of healthy donors, were stimulated with phytohemagglutinin and cultured in vitro in the presence of sodium dichromate (l0-3 - 10-9 M). A high (10-3 M) concentration of sodium dichromate depressed T cell proliferation whereas low levels of dichromate (10-9 M) led to a significant decrease in interleukin 2 production. The results obtained suggest a direct toxic action of sodium dichromate on the functional activity of T cells.Ljudske T stanice izolirane iz periferne krivi zdravih davalaca stimulirane su hernaglutininom i održavane u in vitro kulturi u prisustvu natrijevog dikromata (10-3 - 10-9 M). Visoka koncentracija (10-3 M) natrijevog dikromata smanjila je proliferaoiju T stanica dok su niske razine dikromata (10-9 M) izazvale značajno smanjenje proizvodnje interleukina 2. Dobiveni rezultati upućuju na direktno toksično djelovanje natrijevog dikromata na funkcionalnu aktivnost T stanica
