Institute for Medical Research and Occupational Health
Abstract
Slices of foetal and adult liver were cultured in vitro with various concentrations of Iead ions. A decrease in protein content and an increase in lactate dehydrogenase activity in the culturing medium were found. The changes were dose-dependent, and the foetal liver tissue was found to be more susceptible to the effect of lead than the tissue of adult rats.Rezovi jetre fetusa i odraslog štakora održavani su in vitro u medijima kojima su dodavane različite koncentracije dona olova. Utvrđeno je značajno smanjenje količine proteina u mediju i povećanje aktivnosti laktat dehidrogenaze. Promjene su bile ovisne o koncentraciji olova u mediju. Jetra fetusa bila je osjetljivija na učinke olova negoli jetra odraslog štakora
