Sestre Milosrdnice University hospital and Institute of Clinical Medical Research
Abstract
A wide spectrum of diseases including reactive processes, infections, lymphomas and metastatic tumors can cause enlargement of lymph nodes. The present study on 4062 patients with lymphadenopathy was conducted in the Department of Cytology, Sestre milosrdnice University Hospital Center, Zagreb, during a 10-year period. Of 4062 patients with lymphadenopathy, 1624 were males and 2438 were females, age range from several months to 85 years. Of 4062 fine needle aspiration procedures, 232/4062 (5.7%) samples were nondiagnostic. Lymph node aspirates were benign in 2640/3830 (69%) and malignant in 1190/3830 (31%) cases. Hematologic disease (Hodgkin lymphoma and non-Hodgkin lymphoma) was diagnosed in 482/1190 (40.5%) and metastases in 708/1190 (59.5%) cases. Of 482 patients with hematologic disease, 48/482 (10%) had Hodgkin
lymphomas and 434/482 (90%) non-Hodgkin lymphomas. In the group of malignant lymphadenopathy, there were 212/708 (30%) metastatic squamous cell carcinomas, 177/708 (25%) metastatic
adenocarcinomas, 149/708 (21%) metastases of other carcinomas, and 170/708 (24%) metastases of other malignant tumors. The present study confirmed the fine needle aspiration cytology of enlarged head and neck lymph nodes to be an excellent first-line method to investigate the nature of the lesions.Najčešći uzrok povećanja limfnih čvorova su reaktivni procesi, upale, limfomi ili metastatski tumori. U ovom radu analizirani su punktati 4062 bolesnika punktirana u Kliničkoj jedinici za citologiju KBC-a „Sestre milosrdnice“ u Zagrebu tijekom 10-godišnjeg razdoblja. Muških bolesnika bilo je 1624, a ženskih 2438. Raspon dobi bolesnika bio je od nekoliko mjeseci do 85 godina. Nedijagnostička su bila 232/4062 (5,7%) uzorka. U 2640/3830 (69%) punktata nađene su dobroćudne promjene, dok su u 1190/3830 (31%) punktata nađene zloćudne lezije. Hematološka bolest (Hodgkinov limfom i ne-Hodgkinov limfom) nađena je u 482/1190 (40,5%) punktata, a metastaze u 708/1190 (59,5%) punktata. Od 482 bolesnika s hematološkom bolešću 48/482 (10%) ih je imalo Hodgkinovu bolest, a 434/482 (90%) ne-Hodgkinov limfom. U skupini malignih limfadenopatija bilo je 212/708 (30%) metastaza karcinoma pločastih stanica, 177/708 (25%) metastatskih adenokarcinoma, 149/708 (21%) metastaza ostalih karcinoma i 170/708 (24%) metastaza ostalih malignih tumora. Ovaj rad potvrđuje da je citološka punkcija povećanih limfnih čvorova glave i vrata odlična metoda za ispitivanje naravi navedenih lezija
