U ovom preglednom članku opisan je patomehanizam nastanka bolnog osjeta i put njegovog širenja od mjesta ozljede do korteksa s posebnim osvrtom na pojavu boli kod kronične rane i važnosti njenog pravodobnog i pravovaljanog liječenja Istaknuto je značenje nociceptora (prihvatača bolnih podražaja) i kemijskih posrednika (neurotransmitera) te alogenih tvari koje se oslobađaju na mjestu ozljede i podražuju nocicepcijske neurone. U liječenju je naglašena primjena farmakoterapije (analgetici). Kao temelj racionalne primjene analgetika preporuča se »trostupanjska» ljestvica SZo. Istaknuta je potreba kombinacije farmakoterapije s nefarmakološkim postupcima (kirurški, izikalni). Posebno je istaknut pozitivni učinak VIP svjetla na ubrzanje zacjeljenja kronične rane.This article describes the pathomechanism of the development of painful sensation and its spread from the site of injury to the cortex, with special reference to pain in chronic injury, as well as the importance of timely and proper treatment. Special attention is paid to nociceptors (recipients of painful stimuli) and chemical intermediaries (neurotransmitters), as well as to allogeneic substances released at the site of injury to stimulate nociceptive neurons. Treatment is focused on pharmacotherapy (analgesics). The recommended basis for the rational use of analgesics is the Who "three-degree” scale. The need of combining pharmacotherapy with non-pharmacological elements (surgical, physical) is also stressed. The positive effect of VIP light on faster healing of chronic injuries is especially highlighted
